微小RNA作为颞叶癫痫潜在生物标志物的研究进展  

Research progress in microRNAs as potentialbiomarkers in temporal lobe epilepsy

作　　者：方立雅 刘媛媛 刘家豪 李佳蔚 曾佩 郭津[1,2] FANG Liya;LIU Yuanyuan;LIU Jiahao;LI Jiawei;ZENG Pei;GUO Jin(School of Rehabilitation Medicine,Jiamusi University,Jiamusi,Heilongjiang,154007;Heilongjiang Provincial Key Laboratory of Pediatric Neurorehabilitation,Jiamusi,Heilongjiang,154007;Pediatric Neurology Department,the Third Hospital Affiliated to Jiamusi University,Jiamusi,Heilongjiang,154007)

机构地区：[1]佳木斯大学康复医学院,黑龙江佳木斯154007 [2]黑龙江省儿童神经康复重点实验室,黑龙江佳木斯154007 [3]佳木斯大学附属第三医院小儿神经科,黑龙江佳木斯154007

出　　处：《实用临床医药杂志》2025年第1期130-135,共6页Journal of Clinical Medicine in Practice

基　　金：国家自然科学基金项目(81300122);黑龙江省省属高等学校基本科研业务费团队项目(2022-KYYWF-0653);佳木斯大学东极学术团队“儿童智能康复团队”(DJXSTD202413)。

摘　　要：颞叶癫痫(TLE)是成人中最常见的局灶性癫痫类型,以自发性反复发作为特征,大多数患者伴有药物耐药性和认知功能障碍。微小RNA(miRNA)通过调控转录后基因表达在TLE的病理过程中发挥关键作用。目前TLE的发病机制尚未完全阐明,缺乏有效的临床治疗靶点和预后标志物。本研究综述miRNA在TLE中的表达变化及其作为潜在生物标志物的研究进展,以期为TLE的早期诊断、预后评估以及病理机制研究提供新思路。Temporal lobe epilepsy(TLE)is the most common form of focal epilepsy in adults,characterized by spontaneous recurrent seizures,with most patients experiencing drug resistance and cognitive dysfunction.MicroRNAs(miRNAs)play a critical role in the pathological process of TLE through their regulation of post-transcriptional gene expression.The pathogenesis of TLE has not been fully elucidated,lacking effective clinical therapeutic targets and prognostic markers.This review summarized the expression changes of miRNAs in TLE and their research progress as potential biomarkers,aiming to provide new insights into the early diagnosis,prognosis evaluation,and pathogenic mechanisms of TLE.

关 键 词：微小RNA 颞叶癫痫 生物标志物 非编码RNA 差异性表达 神经炎症 

分 类 号：R748[医药卫生—神经病学与精神病学] R34[医药卫生—临床医学] R456