血脑屏障与胰性脑病关系的研究进展  

Research progress on relationship between blood-brainbarrier and pancreatic encephalopathy

作　　者：李佳霖 罗丹 LI Jialin;LUO Dan(Minda Hospital Affiliated to Hubei University for Nationalities,Enshi,Hubei,445000;Hubei Key Laboratory of Occurrence and Intervention for Rheumatic Diseases,Enshi,Hubei,445000;Medical College of Hubei University for Nationalities,Enshi,Hubei,445000)

机构地区：[1]湖北民族大学附属民大医院,湖北恩施445000 [2]风湿性疾病发生与干预湖北重点实验室,湖北恩施445000 [3]湖北民族大学医学部,湖北恩施445000

出　　处：《实用临床医药杂志》2025年第1期144-148,共5页Journal of Clinical Medicine in Practice

基　　金：湖北省卫生健康委员会重点项目(WJ2019H138);湖北省教育厅科学技术研究中青年人才项目(Q20191904);湖北民族大学附属民大医院博士科研启动基金(bskyqd202419)。

摘　　要：重症急性胰腺炎(SAP)是常见急腹症,而胰性脑病(PE)是SAP并发症之一,表现为胰腺发生炎症时伴随中枢神经系统(CNS)病变。血脑屏障(BBB)作为外周循环与CNS之间的物理生化屏障,在维持CNS稳定微环境方面起着重要作用。BBB受损可导致SAP患者继发性脑水肿。研究BBB与SAP的关系可以为PE的防治提供新思路。本文综述BBB的细胞组成、基本结构、生理学功能,以及炎症因子、肠道微生物群在PE病程中对BBB调节作用的研究现状,探讨PE发生、发展过程中BBB的变化规律。Severe acute pancreatitis(SAP)is a common acute abdominal condition,with pancreatic encephalopathy(PE)being one of its complications,characterized by central nervous system(CNS)lesions when pancreatic inflammation occur.The blood-brain barrier(BBB),serving as a physical and biochemical barrier between peripheral circulation and the CNS,plays a crucial role in maintaining the stable microenvironment of the CNS.Damage to the BBB can lead to secondary cerebral edema in SAP patients.Investigating the relationship between BBB and SAP can provide new insights into the prevention and treatment of PE.This review summarized the cellular composition,basic structure,and physiological functions,as well as the current research status of inflammatory factors and gut microbiota in the course of PE in adjusting BBB,exploring the patterns of BBB changes during the onset and progression of PE.

关 键 词：胰性脑病 重症急性胰腺炎 血脑屏障 脑微血管内皮细胞 紧密连接结构 炎症因子 肠道菌群 

分 类 号：R745[医药卫生—神经病学与精神病学] R576[医药卫生—临床医学] R456