微RNA与物质相关障碍的研究进展  

miRNA and substance-related disorders

作　　者：李雄 丁佳萌 严赫 张冬先 LI Xiong;DING Jia-meng;YAN He;ZHANG Dong-xian(NHC Key Laboratory of Drug Addiction Medicine,School of Forensic Medicine,Kunming Medical University,Kunming 650500,China)

机构地区：[1]国家卫生健康委员会毒品依赖和戒治重点实验室,昆明医科大学法医学院,昆明650500

出　　处：《中国药物依赖性杂志》2024年第6期458-464,共7页Chinese Journal of Drug Dependence

基　　金：云南省科技厅项目(202301AY070001-262);云南省教育厅项目(2023Y0617)。

摘　　要：物质相关障碍(substance-related disorders,SRDs)已经成为了严重的全球性公共卫生和社会问题,其中主要包括使用或滥用酒精、毒品(苯丙胺类、可卡因、阿片类)、药物副作用等所致的相关障碍,但SRDs机制尚未充分阐明。随着对SRDs的深入研究,众多证据显示,微RNA(microRNA,miRNA)在相关物质成瘾中发挥了重要调节作用。miRNA可能通过调节神经突触可塑性、神经系统和免疫系统损伤等,参与了相关物质成瘾发生和发展的神经生物学过程。miRNA在成瘾物质中的作用备受广泛关注,其在药物成瘾的诊断和治疗中具有重大的应用前景。本文对miRNA在成瘾药物中的调节及作用机理进行了系统总结,并试图进一步阐述miRNA在SRDs中的所起到的具体调控作用,为今后的SRDs有关研究提供借鉴。Substance-related disorders(SRDs)are significant global public health and social issues.They primarily involve disorders resulting from the use or abuse of alcohol,drugs(e.g.,amphetamines,cocaine,and opioids),and drug side effects.However,the mechanism behind SRDs have not been fully explained.Through in-depth study of SRDs,evidence suggests that microRNAs(miRNAs)play an important regulatory role in substance addiction.miRNA may be involved in the neurobiological processes associated with the onset and progression of substance addiction by regulating synaptic plasticity,neurological and immune system damage,and more.The use of miRNA in addictive substances has garnered significant attention due to their potential applications in the diagnosis and treatment of drug addiction.This paper provides a systematic summary of the regulation and mechanism of miRNA in addictive drugs,focusing on their specific regulatory roles in SRDs.The aim is to provide a reference for future research on SRDs.

关 键 词：物质相关障碍 MIRNA 酒精 毒品 药物副作用 

分 类 号：R749[医药卫生—神经病学与精神病学]