茶摄入量与抑郁障碍的因果关联:两样本孟德尔随机化研究  

Causal association between tea intake and depressive disorder:A two-sample Mendelian randomization study

作　　者：杜若南 蔡海鹏 杨可冰[1] 李伟[1] 王志仁[1] 赵荣江[1] 王鑫[1] 哈森其木格 DU Ruo-nan;CAI Hai-peng;YANG Ke-bing;LI Wei;WANG Zhi-ren;ZHAO Rong-jang;WANG Xin;HASEN Qimuge(Peking University HuiLongGuan Clinical Medical School/Beijing Huilongguan Hospital,Beijing 100096,China;Geriatrics Department of the First Hospital of Hohhot City,Hohhot 010000,China)

机构地区：[1]北京大学回龙观临床医学院/北京回龙观医院,北京100096 [2]内蒙古自治区呼和浩特市第一医院老年科,呼和浩特010000

出　　处：《中国药物依赖性杂志》2024年第6期511-518,共8页Chinese Journal of Drug Dependence

摘　　要：目的探究茶摄入量与抑郁障碍风险的因果关联。方法使用茶摄入量相关的遗传变异数据作为工具变量,使用抑郁障碍的全基因组关联数据作为结局变量。采用逆方差加权法(IVW)作为孟德尔随机化(MR)的主要分析方法,并将MR-Egger等方法作为补充估计。结果最终纳入41个SNPs进入分析,IVW分析结果显示OR=1.04,PIVW=0.54,即饮茶与抑郁障碍风险无明确因果关系。敏感性分析显示主要结果稳健,无离群值,MR-Presso检验得到了一致的关联效应估计。MR-Egger回归分析未发现潜在多效性。结论本研究从遗传学角度未能提供饮茶降低抑郁障碍风险的证据。Objective To explore the causal association between tea intake and risk of depression.Methods A two-sample Mendelian randomization analysis was performed using Genome-wide Association Study(GWAS)summary data.Inverse variance weighted(IVW)was used as the primary estimate of Mendelian randomization(MR),with additional methods serving as supplementary estimates.Sensitivity analysis was conducted using the MR-PRESSO test and MR-Egger regression.Results Forty-one SNPs were eventually included in the analysis,and IVW analysis showed no clear causal relationship between tea intake and risk of depression(OR=1.04,P_(IVW)=0.54).MR-PRESSO test provided consistent estimates of association effects.MR-Egger regression analysis did not find pleiotropy.Conclusion The present study failed to provide evidence that tea intake reduces the risk of depression from a genetic perspective.We therefore need more experimental studies in the future to elucidate the potential causal association between tea intake and the risk of depression.

关 键 词：茶摄入量 抑郁障碍 全基因组关联研究 孟德尔随机化 因果关系 

分 类 号：R749[医药卫生—神经病学与精神病学]