动态对比增强磁共振成像参数和血清前列腺特异性抗原对前列腺癌的诊断价值及预后的预测价值  

Diagnostic value of dynamic contrast-enhanced magnetic resonance imaging parameters and serum prostate specific antigen in prostate cancer and its predictive value for prognosis

作　　者：梁爽 杨明贵 朱晓云 LIANG Shuang;YANG Minggui;ZHU Xiaoyun(Department of Medical Imaging,Nanshi Hospital of Nanyang,Nanyang 473000,He’nan,China)

机构地区：[1]南阳南石医院医学影像科,河南南阳4730000

出　　处：《癌症进展》2024年第24期2777-2780,共4页Oncology Progress

摘　　要：目的动态对比增强磁共振成像(DCE-MRI)参数和血清前列腺特异性抗原(PSA)水平对前列腺癌(PCa)的诊断价值及预后的预测价值。方法选取84例PCa患者作为观察组,60例前列腺增生患者作为对照组。两组患者均接受DCE-MRI检查及血清PSA水平测定,比较两组患者DCE-MRI参数[速率常数(Kep)、血管外细胞外间隙容积比(V_(e))及容量转移常数(K^(trans))]及PSA水平。对所有患者随访1年,根据随访结果分为预后良好和预后不良患者,比较预后不良和预后良好患者DCE-MRI参数及PSA水平。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析DCE-MRI参数及血清PSA水平单独及联合检测对PCa的诊断价值及预后的预测价值。结果观察组患者Kep、K^(trans)、V_(e)及血清PSA水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。预后不良患者Kep、K^(trans)、V_(e)及血清PSA水平均明显高于预后良好患者,差异均有统计学意义(P﹤0.01)。ROC曲线显示,DCE-MRI参数及血清PSA水平诊断PCa和预测患者预后的AUC均﹥0.7,有一定的诊断/预测价值,且联合检测的诊断/预测价值最高。结论DCE-MRI参数和血清PSA水平可用于诊断PCa及预测患者预后,其临床应用价值较高。Objective To investigate the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters and serum prostate specific antigen(PSA)level in prostate cancer and its predictive value for prognosis.Method A total of 84 patients with PCa were selected as the observation group and 60 patients with hyperpla-sia of prostate were selected as the control group.Both groups received DCE-MRI examination and serum PSA level de-tection.The DCE-MRI parameters[rate constant(Kep),extravascular extracellular volume fraction(Ve),volume transfer constant(Ktrans)]and PSA level were compared between the two groups.All patients were followed up for one year and di-vided into patients with good prognosis and patients with poor prognosis according to the follow-up results.DCE-MRI pa-rameters and PSA levels were compared between patients with poor prognosis and patients with good prognosis.Receiver operating characteristic(ROC)curve and area under the curve(AUC)were used to analyze the diagnostic and prognostic value of DCE-MRI parameters and serum PSA level single and combined detection in PCa.Result The K_(ep),K^(trans),V_(e)and serum PSA level in observation group were significantly higher than those in control group,and the differences were sta-tistically significant(P<0.01).The K_(ep),K^(trans),V_(e)and serum PSA level in patients with poor prognosis were significantly higher than those in patients with good prognosis,and the differences were statistically significant(P<0.01).ROC curve showed that the AUC of DCE-MRI parameters and serum PSA level in diagnosing PCa and predicting prognosis of pa-tients were>0.7,which had certain diagnostic/predictive value,and the combined detection diagnostic/predictive value was the highest.Conclusion DCE-MRI parameters and serum PSA level can be used to diagnose PCa and predict the prognosis,and their clinical application values are high.

关 键 词：前列腺癌 前列腺特异性抗原 动态对比增强磁共振成像 诊断 预后 

分 类 号：R737.25[医药卫生—肿瘤]