四物汤加味医院代煎剂常温稳定性研究  

Study on the Stability of the Hospital Substitute Decoction of Siwutang Jiawei(四物汤加味)at Room Temperature

作　　者：张国哲 韩越[2] ZHANG Guozhe;HAN Yue(Jiangsu Mecidal College,Yancheng Jiangsu 224005,China;Jiangsu Province Hospital of Chinese Medicine,Nanjing Jiangsu 210029,China)

机构地区：[1]江苏医药职业学院,江苏盐城224005 [2]江苏省中医院,江苏南京210029

出　　处：《中医药导报》2025年第1期77-80,85,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：江苏省卫生计生委科研课题(Z2017017)。

摘　　要：目的:建立一种考察四物汤加味医院代煎液中指标成分稳定性及微生物限度检查的方法,为医院代煎液的保存时间提供依据和参考。方法:采用HPLC法测定四物汤加味(SWTJW)代煎液常温放置0、1、3、9、16、23、30、35 d的指标成分芍药苷、二苯乙烯苷、淫羊藿苷的含量变化,并测定pH值、相对密度及微生物限度。结果:代煎液中芍药苷和淫羊藿苷的含量在35 d内稳定(含量降低小于5%),二苯乙烯苷的含量逐渐下降(35 d含量降低17.64%),代煎液的pH值、相对密度在35 d内均未见明显变化,微生物限度符合要求。结论:四物汤加味代煎剂在常温保存35 d基本稳定,但何首乌主要成分二苯乙烯苷含量有所降低。Objective:To establish a method for examining the stability of indicator components and microbial limit testing in hospital prescription decoctions of Siwutang Jiawei(SWTJW),providing a basis and reference for the storage time of hospital decoctions.Methods:HPLC was used to determine the changes in the content of indicator components such as paeoniflorin,stilbene glycoside,and icariin in the decoction of SWTJW at room temperature for 0,1,3,9,16,23,30,and 35 days.The pH value,relative density,and microbial limit were also measured.Results:The content of paeoniflorin and icariin in the substitute decoction remained stable within 35 days(with a decrease of less than 5%),while the content of stilbene glycoside gradually decreased(with a decrease of 17.64%after 35 days).The pH value and relative density of the substitute decoction did not show significant changes within 35 days,and the microbial limit met the requirements.Conclusion:The Siwutang Jiawei(SWTJW)is basically stable after being stored at room temperature for 35 days,but the main component of Heshouwu(Polygoni multiflori radix),stilbene glycoside,decreases significantly.

关 键 词：四物汤加味 代煎剂 含量 HPLC 稳定性 微生物限度 

分 类 号：R284.1[医药卫生—中药学]