“天人合一”观下女性难治性慢性咳嗽证素、“七七”年龄及节气分布规律  

The Distribution of Syndrome Elements,the"Qi-Qi"Age and the Solar Terms in Female Chronic Refractory Cough Under"Unity of Heaven and Man"

作　　者：谢楚溪 庄明月 程锦涛 刘莲莲 王成祥 XIE Chuxi;ZHUANG Mingyue;CHENG Jintao;LIU Lianlian;WANG Chengxiang(Beijing University of Chinese Medicine,Beijing 100029,China;Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学第三附属医院,北京100029

出　　处：《中医药导报》2025年第1期90-95,共6页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(82074389);首都卫生发展科研专项项目(首发2022-2-7034);北京中医药文化资源调专题(WHZX-2020-94)。

摘　　要：目的:基于“天人合一”观探究女性难治性慢性咳嗽中医证素特点、“七七”年龄分布及发病节气规律。方法:收集2020年1月至2024年5月在北京中医药大学第三附属医院就诊的584例女性难治性慢性咳嗽患者的临床资料(基本资料、相关因素、中医四诊),采取证素评分矩阵确定中医证素,证素间采用Apriori算法进行关联规则分析,因子分析提取公因子,k-means聚类法分析公因子组合情况,归纳年龄、证候、节气分布规律。结果:共纳入584例女性患者,以“七七”患者居多。提取以阴虚、痰、气虚、气滞、肺及肝等为主的病性病位证素24个。10个因子组合共聚为4类证型:血虚风燥证、气阴两虚证、肝郁气滞证、风痰阻络证。发病节气“白露”“小寒”占重要比重。结论:女性难治性慢性咳嗽以气阴两虚证、风痰阻络证为主,不同“七七”年龄段证候分布比例存在差异,且受节气影响。Objective:To explore the distribution of syndrome elements,the"qi-qi"age and the solar terms in female chronic refractory cough under"Unity of Heaven and Man".Methods:Collect the clinical data of 584 female patients with chronic refractory cough who were treated in the outpatient service of Beijing University of Chinese Medicine Third Affiliated Hospital from January 2020 to May 2023(including basic information,relevant factors,and four diagnostic methods of traditional Chinese medicine).The syndrome elements were determined using a syndrome element scoring matrix,and the association rules were analyzed using the Apriori algorithm.The common factors were extracted using factor analysis,and the combination of common factors was analyzed using k-means clustering method.The distribution patterns of age,syndrome,and solar terms were summarized.Results:A total of 584 female patients is included,with a majority of patients in the"qi-qi"group.A total of 24 syndrome elements of disease location were extracted,including Yin deficiency,phlegm,Qi deficiency,Qi stagnation,lung and liver.The 10 factors were combined into 4 types of syndromes:blood deficiency and wind dryness syndrome,Qi and Yin deficiency syndrome,liver depression and Qi stagnation syndrome,and wind phlegm obstruction syndrome.The solar terms"Bailu"and"Xiaohan"account for an important proportion.Conclusion:Female chronic refractory cough is mainly characterized by Qi and Yin deficiency syndrome and wind phlegm obstruction syndrome. There are differences in the distribution of syndromes among different "qi-qi" groups, and there are statistical differences in the impact of solar terms.

关 键 词：难治性慢性咳嗽 女性 七七理论 节气 中医证素 病性 病位 天人合一 

分 类 号：R256.11[医药卫生—中医内科学]