Neurobiology of Obsessive–Compulsive Disorder from Genes to Circuits:Insights from Animal Models  

作　　者：Ying-Dan Zhang Dong-Dong Shi Zhen Wang 

机构地区：[1]Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,200030,China [2]Shanghai Key Laboratory of Psychotic Disorders,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,201108,China [3]Shanghai Intelligent Psychological Evaluation and Intervention Engineering Technology Research Center,Shanghai,200030,China

出　　处：《Neuroscience Bulletin》2024年第12期1975-1994,共20页神经科学通报(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(82230045,82071518,and 32271066);the Shanghai Science and Technology Committee(20XD1423100 and 23QA1408300);the Xuhui District Artificial Intelligence Medical Hospital Cooperation Project(2021-005);the Shanghai Municipal Education Commission(2021-01-07-00-02-E0086).

摘　　要：Obsessive-compulsive disorder(OCD)is a chronic,severe psychiatric disorder that has been ranked by the World Health Organization as one of the leading causes of illness-related disability,and first-line interventions are limited in efficacy and have side-effect issues.However,the exact pathophysiology underlying this complex,heterogeneous disorder remains unknown.This scenario is now rapidly changing due to the advancement of powerful technologies that can be used to verify the function of the specific gene and dissect the neural circuits underlying the neurobiology of OCD in rodents.Genetic and circuit-specific manipulation in rodents has provided important insights into the neurobiology of OCD by identifying the molecular,cellular,and circuit events that induce OCD-like behaviors.This review will highlight recent progress specifically toward classic genetic animal models and advanced neural circuit findings,which provide theoretical evidence for targeted intervention on specific molecular,cellular,and neural circuit events.

关 键 词：Obsessive-compulsive disorder(OCD) Animal models GENES CIRCUITS NEUROBIOLOGY 

分 类 号：R749.7[医药卫生—神经病学与精神病学]