青岛市体检人群血清铁蛋白和红细胞参数与2型糖尿病的关联研究  

Relationship between serum ferritin levels and red blood cell parameters with the risk of type 2 diabetes mellitus in medical examination individuals from Qingdao City

作　　者：马岩[1] 房圆圆 王锦雨 吕建峰 贾茹 马爱国[1] 熊珂 Ma Yan;Fang Yuanyuan;Wang Jinyu;Lyu Jianfeng;Jia Ru;Ma Aiguo;Xiong Ke(Institute of Nutrition and Health,Qingdao University,Qingdao 266071,China;Infection Management Office,The Affiliated Hospital of Shandong Second Medical University,Weifang 252422,China;Department of Food Hygiene,Tai′an Center for Disease Control and Prevention in Shandong Province Tai'an 271000,China)

机构地区：[1]青岛大学营养与健康研究院,青岛266071 [2]山东第二医科大学附属医院感染管理办公室,潍坊252422 [3]山东省泰安市疾病预防控制中心食品卫生科,泰安271000

出　　处：《中华预防医学杂志》2025年第1期16-21,共6页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金青年项目(82103847);山东省自然科学基金青年项目(ZR2021QH165);国家自然科学基金面上项目(81373000)。

摘　　要：目的探讨体检人群血清铁蛋白及红细胞参数与2型糖尿病患病风险的关联。方法将2014—2015年11408名(40~70岁)青岛市某医院体检人群纳入研究,通过问卷调查、体格检查、血液生化指标、血清铁蛋白和相关红细胞参数检测收集信息,采用多因素logistic回归模型分析血清铁蛋白和红细胞参数与2型糖尿病的关联情况,采用线性回归模型分析血清铁蛋白和红细胞参数与空腹血糖的关联情况。结果研究对象年龄M(Q 1,Q 3)为51(45,58)岁,其中男性占55.3%(6305名)。女性2型糖尿病患病率为5.9%(300/5103),低于男性[13.0%(817/6305)](P<0.001)。调整年龄、性别、BMI、吸烟、饮酒和糖尿病家族史等因素后,血清铁蛋白水平与2型糖尿病和空腹血糖水平均呈正向关联,其OR(95%CI)和β(95%CI)值分别为1.70(1.37,2.11)和0.002(0.002,0.003);血红蛋白、红细胞计数和红细胞压积与2型糖尿病和空腹血糖均呈正向关联[前者OR(95%CI)值分别为:1.72(1.32,2.24)、1.91(1.51,2.41)和1.52(1.17,1.97)],后者β(95%CI)值分别为:0.008(0.006,0.011)、0.365(0.286,0.445)、2.543(1.564,3.521),平均红细胞体积与2型糖尿病和空腹血糖均呈负向关联[OR(95%CI)和β(95%CI)值分别为0.54(0.45,0.66)和-0.017(-0.023,-0.011)(均P<0.001)。结论青岛市体检人群血清铁蛋白和相关红细胞参数与2型糖尿病和空腹血糖均有关联。Objective To investigate the association between serum ferritin levels,erythrocyte parameters,and the risk of developing type 2 diabetes mellitus.Methods A total of 11408 subjects aged 40 to 70 years who underwent physical examinations at a hospital in Qingdao from 2014 to 2015 were enrolled in the study.Data were collected through questionnaires,physical examinations,and assessments of blood biochemical indices,serum ferritin,and related erythrocyte parameters.A multivariate logistic regression model was employed to analyze the relationship of serum ferritin and red cell parameters with type 2 diabetes mellitus,while a linear regression model was utilized to examine the association between serum ferritin,red cell parameters and fasting blood glucose levels.Results The median(Q 1,Q 3)age of the subjects was 51(45,58)years,with 55.3%(6305)being male.The prevalence of type 2 diabetes in women was 5.9%(300/5103),which was lower than that in men[13.0%(817/6305)](P<0.001).After adjusting for age,sex,body mass index(BMI),smoking status,alcohol consumption,and family history of diabetes,serum ferritin levels were found to be positively associated with both type 2 diabetes and fasting blood glucose levels,with OR(95%CI)andβ(95%CI)values of 1.70(1.37,2.11)and 0.002(0.002,0.003),respectively.Additionally,hemoglobin,red blood cell count,and hematocrit were positively correlated with type 2 diabetes and fasting blood glucose,with OR(95%CI)values of 1.72(1.32,2.24),1.91(1.51,2.41),and 1.52(1.17,1.97),andβ(95%CI)values of 0.008(0.006,0.011),0.365(0.286,0.445),and 2.543(1.564,3.521),respectively.Conversely,mean erythrocyte volume was negatively associated with type 2 diabetes and fasting blood glucose,with OR(95%CI)andβ(95%CI)values of 0.54(0.45,0.66)and-0.017(-0.023,-0.011),respectively(all P values<0.001).Conclusion The findings indicate that serum ferritin and related erythrocyte parameters are significantly correlated with the risk of type 2 diabetes mellitus and fasting blood glucose levels.

关 键 词：铁蛋白质类 红细胞 糖尿病 2型 横断面研究 

分 类 号：R587.1[医药卫生—内分泌]