Impact of ambient temperatures on Alzheimer's disease and other dementia mortality among elderly patients aged 60 years and older in China  

作　　者：Rui ZHANG Lu SUN Ai-Nan JIA Si-Yuan WU Yu WANG Song-Wang WANG Qing GUO Yu-Jie MENG Juan LIANG Wan HUANG Yong-Hong LI Jing WU 

机构地区：[1]National Center for Chronic and Noncommunicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100050,China [2]Chinese Center for Disease Control and Prevention,Beijing 102206,China [3]State Key Laboratory of Infectious Disease Prevention and Control,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China [4]Sprott School of Business,Carleton University,Ottawa Ontario K1S 5B6,Canada [5]China CDC Key Laboratory of Environment and Population Health,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China

出　　处：《Advances in Climate Change Research》2024年第6期1088-1095,共8页气候变化研究进展(英文版)

基　　金：supported by the National Key Research and Development Program of China(2023YFC2308703,2022YFC2602301);the Project of Prevention and Intervention on Major Diseases for Elderly in China,NCNCD(00240201307);the Science and Technology Fundamental Resources Investigation Program of China(2017FY101201).

摘　　要：China has a large number of patients with Alzheimer's disease(AD)and types of other dementia,which places a heavy burden on the public health and medical systems.As global climate change results in more frequent extreme weather events,and there is a current lack of understanding regarding the impact of non-optimal temperatures,especially cold,on AD and other dementia mortality,the study aimed to identify patterns of temperature sensitivity in order to inform targeted public health strategies.The records of 399,214 decedents aged 60 years and older who died due to AD or other dementias from 2013 to 2020 were obtained from the China Cause of Death Reporting System.Using an individual-level time-stratified case-crossover study design,the relationships between ambient temperatures and AD and other dementia mortality were quantified using conditional logistic regression combined with the distributed lag nonlinear model.In addition,the attributable fractions(AFs)of mortality due to non-optimal ambient temperatures were calculated.The study found that both low and high non-optimal temperatures were associated with an increased risk of death from AD and other dementias,with an inverted J-shaped exposure–response curve.Moreover,the AFs of mortality due to full,low and high non-optimal temperatures with lag0–14 were 5.81%(95%empirical confidence interval[eCI]:4.89%,6.72%),5.24%(95%eCI:4.15%,6.27%)and 0.58%(95%eCI:0.27%,0.90%),respectively.Importantly,AFs varied across administrative regions,influenced by factors such as climate,geography,sociodemographic characteristics and socioeconomic factors.These findings can inform clinical and public health practices to reduce the mortality burden due to non-optimal temperatures on elderly populations with AD and other dementias.

关 键 词：Alzheimer's disease and other dementias DEATHS Ambient temperatures Non-optimal temperatures Attributable fractions Individual-level analysis 

分 类 号：R749.16[医药卫生—神经病学与精神病学]