青钱柳叶中1个新的四氢萘酮苷类化合物  

A new tetralone glycoside in leaves of Cyclocarya paliurus

作　　者：郭婷思 黄沁 胡琪琪 黄费炳 谢青玲 袁汉文 王炜[1] 翦雨青 GUO Ting-si;HUANG Qin;HU Qi-qi;HUANG Fei-bing;XIE Qing-ling;YUAN Han-wen;WANG Wei;JIAN Yu-qing(Traditional Chinese Medicine and Ethnomedicine Innovation&Development International Laboratory,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学中医药民族医药国际联合实验室,湖南长沙410208

出　　处：《中国中药杂志》2025年第1期146-151,共6页China Journal of Chinese Materia Medica

基　　金：国家中医药管理局中药炮制技术传承基地开放基金项目(2022ZYPZ08);湖南省教育厅优秀青年项目(22B0388);湖南省中医药管理局一般项目(B2023143);湖南省天然药物资源与功能重点实验室开放项目(2022ZYYGN03);湖南中医药大学研究生创新课题(2023CX141)。

摘　　要：运用硅胶、C_(18)反相硅胶、Sephadex LH-20凝胶及半制备型高效液相等色谱技术对青钱柳Cyclocarya paliurus叶中的化学成分进行分离和纯化,通过UV、IR、NMR、MS、计算ECD以及文献数据对比等多种方法共鉴定出6个化合物,分别为cyclopaloside D(1)、boscialin(2)、(5R,6S)-6-hydroxy-6-[(E)-3-hydroxybut-1-enyl]-1,1,5-trimethylcyclohexanone(3)、3S,5R-dihydroxy-6R,7-megastigmadien-9-one(4)、3S,5R-dihydroxy-6S,7-megastigmadien-9-one(5)、gingerglycolipid A(6)。其中化合物1为新的四氢萘酮苷类化合物,化合物2~6均为首次从青钱柳叶中分离得到。此外,化合物1表现出较好的抗氧化活性,其对DPPH和ABTS自由基清除活性的IC_(50)分别为(454.20±31.81)、(881.82±42.31)μmol·L^(-1)。The chemical constituents from leaves of Cyclocarya paliurus were isolated and purified by chromatography on silica gel,C_(18)reverse-phase silica gel,and Sephadex LH-20 gel,as well as semi-preparative high-performance liquid chromatography.Six compounds were identified by UV,IR,NMR,MS,calculated ECD,and comparison with literature data as cyclopaloside D(1),boscialin(2),(5R,6S)-6-hydroxy-6-[(E)-3-hydroxybut-1-enyl]-1,1,5-trimethylcyclohexanone(3),3S,5R-dihydroxy-6R,7-megastigmadien-9-one(4),3S,5R-dihydroxy-6S,7-megastigmadien-9-one(5),and gingerglycolipid A(6),respectively.Among them,compound 1 was identified as a new tetralone glycoside,and compounds 2-6 were isolated from leaves of C.paliurus for the first time.Furthermore,compound 1 exhibited strong antioxidant activity,with the IC_(50)of(454.20±31.81)μmol·L^(-1)and(881.82±42.31)μmol·L^(-1)in scavenging DPPH and ABTS free radicals,respectively.

关 键 词：青钱柳叶 化学成分 四氢萘酮苷 抗氧化活性 

分 类 号：R284.1[医药卫生—中药学]