急性牙髓炎患者血清G-CSF,sST2水平联合检测对根管治疗期间急症发生及治疗后疼痛程度的影响  

Impacts of combined detection of serum G-CSF and sST2 levels on the occurrence of emergencies during root canal therapy and the degree of pain after treatment in patients with acute pulpitis

作　　者：熊梦琳 韩婧 赵今[1,2] XIONG Meng-lin;HAN Jing;ZHAO Jin(Department of Dentistry and Endodontics,The First Affiliated Hospital of Xinjiang Medical University,Xinjiang Urumqi 830054,China;Xinjiang Institute of Stomatology,Xinjiang Urumqi 830054,China)

机构地区：[1]新疆医科大学第一附属医院(附属口腔医院)牙体牙髓科,新疆乌鲁木齐830054 [2]新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐830054

出　　处：《临床口腔医学杂志》2025年第1期24-29,共6页Journal of Clinical Stomatology

摘　　要：目的:探讨急性牙髓炎患者血清粒细胞集落刺激因子(granulocyte colony-stimulating factor,G-CSF),可溶性生长刺激表达基因2蛋白(soluble growth stimulating gene 2 protein,sST2)水平联合检测对根管治疗期间急症发生及治疗后疼痛程度的影响。方法:选取2022年8月~2023年8月期间本院收治的急性牙髓炎患者130例作为研究组,根据根管治疗期间有无急症的发生,分为发生急症组(28例)、未发生急症组(102例)。治疗后基于视觉模拟评分(visual analogue scale,VAS)系统评估疼痛程度分为轻度组(54例)、中度组(47例)与重度组(29例)。另选取同期98名健康体检者作为对照组。酶联吸附法(ELISA)检测研究组与对照组血清G-CSF、sST2水平;急性牙髓炎血清G-CSF、sST2水平与VAS评分的相关性采用Spearman法分析;多因素Logistic回归分析急性牙髓炎患者治疗后疼痛程度影响因素。受试者工作特征(receiver operating characteristic,ROC)曲线评估血清G-CSF、sST2对急性牙髓炎根管治疗期间急症发生及治疗后疼痛程度预测价值。结果:急性牙髓炎患者血清G-CSF、sST2水平均显著高于对照组(P<0.05)。与未发生急症组相比,发生急症组患者血清G-CSF、sST2水平均显著升高(P<0.05)。在不同的疼痛程度分组中,重度组患者血清G-CSF、sST2水平均高于轻度组和中度组(P<0.05)。血清G-CSF水平与VAS评分呈正相关系(r=0.669,P<0.05);血清sST2水平与VAS评分呈正相关系(r=0.563,P<0.05)。重度组与轻/中度组患者的根充效果、VAS评分相比,差异有统计学意义(P<0.05)。血清G-CSF、sST2水平升高、根充效果欠填/超充、VAS评分升高是急性牙髓炎治疗后发生重度疼痛的独立危险因素(P<0.05)。ROC曲线结果发现血清G-CSF、sST2水平预测急性牙髓炎根管治疗期间急症的发生的曲线下面积(area under the curve,AUC)分别为0.848、0.825、0.929,二者联合预测价值高于单独预测(Z_(二者联合-G-CSF)=2.230,P=0.026;Objective:To investigate the impacts of combined detection of serum levels of granulocyte colony-stimulating factor(G-CSF)and soluble growth stimulating gene 2 protein(sST2)on the occurrence of emergencies during root canal therapy and the degree of pain after treatment in patients with acute pulpitis.Methods:From August 2022 to August 2023,130 patients with acute pulpitis accepted by our hospital were regarded as the study group.They were separated into an emergency group(28 cases)and a non emergency group(102 cases)based on the occurrence of any emergency during root canal treatment.After treatment,the pain level was evaluated using the visual analog scale(VAS)system,and the patients were separated into mild group(54 cases),moderate group(47 cases),and severe group(29 cases).Another 98 healthy examinees from the same period were collected as the reference group.ELISA was applied to detect serum G-CSF and sST2 levels in the study group and reference group.The correlation between serum G-CSF,sST2 levels and VAS score in acute pulpitis was analyzed using Spearman method,multivariate Logistic regression was applied to analyze the factors influencing the degree of pain in patients with acute pulpitis after treatment.Receiver operating characteristic(ROC)curve was applied to evaluate the diagnostic value of serum G-CSF and sST2 for the occurrence of emergencies during root canal therapy and the degree of pain after treatment in acute pulpitis.Results:The serum levels of G-CSF and sST2 in patients with acute pulpitis were obviously higher than those in reference group(P<0.05).Compared with the non emergency group,the serum levels of G-CSF and sST2 in the emergency group were obviously increased(P<0.05).In different pain severity groups,the serum levels of G-CSF and sST2 in the severe group were higher than those in the mild and moderate groups(P<0.05).The serum G-CSF level was positively correlated with VAS score(r=0.669,P<0.05),the serum level of sST2 was positively correlated with VAS score(r=0.563,P<0.05).There was

关 键 词：急性牙髓炎 粒细胞集落刺激因子 可溶性生长刺激表达基因2蛋白 疼痛程度 预测价值 

分 类 号：R781.31[医药卫生—口腔医学]