基于病机兼化思想探讨非酒精性脂肪性肝病病机  

Exploration on the pathogenesis of non-alcoholic fatty liver disease based on the concept of pathogenesis conversion

作　　者：刘西洋[1] 胡镜清 吴文军[1] 李霞[1] 冯全生[1] LIU Xiyang;HU Jingqing;WU Wenjun;LI Xia;FENG Quansheng(Chengdu University of Traditional Chinese Medicine,Chengdu 611100,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]成都中医药大学,成都611100 [2]天津中医药大学,天津301617

出　　处：《中华中医药杂志》2024年第12期6392-6395,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：四川省自然科学基金青年基金项目(No.2023NSFSC1788);成都中医药大学“杏林学者”学科人才科研提升计划(博士后专项)(No.HSH2021032)。

摘　　要：非酒精性脂肪性肝病(NAFLD)自然史呈单纯性肝脂肪变、脂肪性肝炎、肝硬化及肝细胞癌进展。目前本病尚无特效治疗药物,早期干预、防止病情进展是防治的关键。文章基于病机兼化理论框架,分析NAFLD不同病理阶段的病机特点,并结合本病的现代分子生物学机制阐释与论证,揭示本病病机演化规律,有助于动态把握疾病进程,未病先防,既病防变。同时,根据本病不同阶段的病机特点,分析辨治要点,并强调重视药物作用“层次”,望对本病防治、预后判断、准确用药及科学研究有所启示。The natural history of non-alcoholic fatty liver disease(NAFLD)is characterized by simple hepatic steatosis,steatohepatitis,progression of cirrhosis and liver cancer.At present,there is no specific treatment drug for this disease.Early intervention to prevent the progression of the disease is the key to prevention and treatment.This article is based on the theoretical framework of pathogenesis conversion,analyzing the pathogenesis characteristics of NAFLD at different pathological stages,and combining with the modern molecular biology mechanism of this disease to explain and demonstrate the evolution law of this disease pathogenesis,which helps to dynamically grasp the disease process,prevent disease before it occurs,and prevent disease from changing.At the same time,based on the pathogenesis characteristics of different stages,analyze the key points of differentiation and treatment,pay attention to the‘hierarchy’of drug action,and hope to provide inspiration for the prevention and treatment,prognosis judgment,accurate medication,and scientific research of this disease.

关 键 词：非酒精性脂肪性肝病 核心病机 病机兼化 

分 类 号：R57[医药卫生—消化系统]