加味还少丹颗粒治疗老年衰弱症患者临床疗效及对血清炎症因子的影响  

Clinical efficacy evaluation of Jiawei Huanshaodan Granules in the treatment of elderly patients with frailty and its impact on serum inflammatory factors

作　　者：刘颖[1] 方晗语 刘明非 洪政 陈欣[1] 王朋 李求兵[1] 张洪春[2,3] LIU Ying;FANG Hanyu;LIU Mingfei;HONG Zheng;CHEN Xin;WANG Peng;LI Qiubing;ZHANG Hongchun(The Second Department of Health Care,China-Japan Friendship Hospital,Beijing 100029,China;Beijing University of Chinese Medicine,Beijing 100029,China;Department of Pulmonary Diseases of Traditional Chinese Medicine,Respiratory Center of China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院保健部二部,北京100029 [2]北京中医药大学,北京100029 [3]中日友好医院呼吸中心中医肺病科,北京100029

出　　处：《中华中医药杂志》2024年第12期6894-6898,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中央保健科研课题(No.2020YB26);中医药传承与创新“百千万”人才工程(岐黄工程)(No.2019-QTL-003);中国康复医学会科技发展项目(No.KFKT-2022-005)。

摘　　要：目的:观察加味还少丹颗粒治疗老年衰弱症患者临床疗效及对血清炎症因子的影响。方法:2021年10月至2023年1月于中日友好医院招募64例受试者,期间脱落4例,最终试验组29例,对照组31例,两组均予基础治疗,在此基础上,试验组予加味还少丹颗粒,对照组予安慰剂,疗程12周。观察两组患者治疗前后Tilburg衰弱评估量表(TFI)、蒙特利尔认知评估量表(MoCA)、日常生活能力量表(ADL)评分,以及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平和安全性指标的变化。结果:治疗后两组TFI和ADL评分、血清TNF-α、IL-6含量均较治疗前显著降低(对照组血清TNF-α、IL-6除外)(P<0.01,P<0.05);且试验组各值显著低于对照组(P<0.01,P<0.05)。治疗后两组MoCA评分较治疗前显著升高(P<0.01),且试验组MoCA评分显著高于对照组(P<0.01)。结论:加味还少丹颗粒能够改善老年衰弱症的临床症状,其机制可能与下调炎症因子,抑制炎症反应有关。Objective:To observe the clinical efficacy of Jiawei Huanshaodan Granules in treating elderly frailty patients and its impact on serum inflammatory factors.Methods:Form October 2021 to January 2023,64 subjects were recruited from China-Japan Friendship Hospital,with 4 subjects dropping out during the trial period,in the end,there were 29 subjects in the trial group and 31 subjects in the control group.Both groups were given basic treatment.On this basis,the test group was given Jiawei Huanshaodan Granules,and the control group was given placebo for a course of 12 weeks.The changes in Tilburg frailty indicator(TFI)scale scores,Montreal cognitive assessment(MoCA)scores,activity of daily living(ADL)scores,serum tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)levels,and safety indicators were observed before and after treatment in both groups of patients.Results:After treatment,the TFI and ADL scores,serum TNF-α and IL-6 in both groups were lower than those before treatment(the control group serum TNF-α and IL-6 were excluded)(P<0.01,P<0.05);the average score of the test group was lower than that of the control group(P<0.01,P<0.05).After treatment,the MoCA score in both groups were higher than before treatment(P<0.01),and the average score in the test group was higher than that in the control group(P<0.01).Conclusion:Jiawei Huanshaodan Granules can effectively improve the clinical symptoms of elderly frailty,and its mechanism may be related to down-regulation of inflammatory factors and inhibiting inflammatory reactions.

关 键 词：老年衰弱症 加味还少丹颗粒 蒙特利尔认知评估量表 Tilburg衰弱评估量表 炎症因子 机制 临床疗效 日常生活能力量表 

分 类 号：R74[医药卫生—神经病学与精神病学]