Dragocin家族海洋天然产物四氢吡咯母核的合成  

Synthesis of tetrahydropyrrole skeleton of dragocin family marine natural products

作　　者：庞若尘 刘涛 张鑫宇 董浩 王杨 PANG Ruochen;LIU Tao;ZHANG Xinyu;DONG Hao;WANG Yang(Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;Laboratory for Marine Drugs and Bioproducts,Qingdao Marine Science and Technology Center,Qingdao 266237,China)

机构地区：[1]中国海洋大学海洋药物教育部重点实验室,医药学院,山东青岛266003 [2]青岛海洋科技中心海洋药物与生物制品功能实验室,山东青岛266237

出　　处：《中国海洋药物》2024年第6期57-61,共5页Chinese Journal of Marine Drugs

基　　金：国家自然科学基金项目(22201270)资助。

摘　　要：目的 采用化学合成的方法对dragocin家族海洋天然产物进行合成研究,完成了dragocin家族海洋天然产物四氢吡咯母核的合成。方法 以对二氧环己酮和氨基乙醛的衍生物为起始原料,经有机小分子催化的aldol反应、串联的氢化/还原胺化反应、丙酮叉迁移、氧化、格氏反应等步骤合成目标化合物。结果 以对二氧环己酮和氨基乙醛的衍生物为起始原料,经6步反应,以22%的总产率完成了dragocin家族海洋天然产物四氢吡咯母核的合成,为天然产物的合成提供了基础。Objective The synthetic study on dragocin family marine natural products was conducted.The construction of core tetrahydropyrrole skeleton was accomplished.Methods The target compound was synthesized from dioxanone and aminoacetaldehyde derivatives through organocatalytic aldol,tandem hydrogenation/reductive amination,migration,oxidation,and Grignard reaction.Results The synthesis of core tetrahydropyrrole skeleton in dragocin family marine natural products was completed in 6 steps with 22%yield,providing a foundation for total synthesis of natural products.

关 键 词：海洋天然产物 dragocin 四氢吡咯 

分 类 号：R914[医药卫生—药物化学]