内源性生物活性小分子与血管钙化  

Endogenous bioactive small molecules and vascular calcification

作　　者：王蕊 柴三葆[4] 齐永芬[1,2,3] WANG Rui;CHAI Sanbao;QI Yongfen(Laboratory of Cardiovascular Bioactive Molecule,School of Basic Medical Sciences,Peking University,Beijing 100083,China;State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,Beijing 100083,China;Department of Pathogen Biology,School of Basic Medical Sciences,Peking University Health Science Center,Beijing 100083,China;Department of Endocrinology and Metabolism,Peking University International Hospital,Beijing 102206,China)

机构地区：[1]北京大学基础医学院心血管生物活性分子实验室,北京市100083 [2]北京大学血管稳态与重构国家重点实验室,北京市100083 [3]北京大学医学部基础医学院病原生物学系,北京市100083 [4]北京大学国际医院内分泌科,北京市102206

出　　处：《中国动脉硬化杂志》2025年第1期1-8,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(32271153、31872790);北京市自然科学基金项目(7232226)。

摘　　要：内源性生物活性小分子具有分子量小、生物活性高、免疫原性小、合成代谢迅速等特点,在维持血管稳态中发挥重要作用。血管钙化(VC)是体内钙磷在血管壁的异常沉积。内源性生物活性小分子如心血管活性多肽、脂肪因子及气体分子等通过多种机制参与VC的进程。本文综述内源性生物活性小分子与VC的发生发展及其相关机制的研究进展。Endogenous bioactive small molecules are characterized by low molecular weight,high biological activity,low immunogenicity,and rapid synthesis and metabolism,play a pivotal role in maintaining vascular homeostasis.Vascular calcification(VC)is a abnormal deposition of calcium and phosphorus in the vessel wall.Endogenous bioactive small molecules such as cardiovascular bioactive peptides,adipokines and gaseous molecules participate in the process of VC through various mechanisms.This review summarises the advances in relationship between endogenous bioactive small molecules and the occurrence,development,and related mechanisms of VC.

关 键 词：血管钙化 内源性生物活性小分子 心血管活性多肽 脂肪因子 气体分子 

分 类 号：R363.1[医药卫生—病理学] R5[医药卫生—基础医学]