硬化性腺病和浸润性导管癌组织的Mueller矩阵表征  

Mueller-Matrix Characterization of Sclerosing Adenosis and Invasive Ductal Carcinoma Tissues

作　　者：褚金奎[1] 丁晓涵 陈永台 黄波[3,4,5] 蒋冰[3] 辛本达[1] Chu Jinkui;Ding Xiaohan;Chen Yongtai;Huang Bo;Jiang Bing;Xin Benda(School of Mechanical Engineering,Dalian University of Technology,Dalian 116023,Liaoning,China;Research Center for Frontier Fundamental Studies,Zhejiang Lab,Hangzhou 311121,Zhejiang,China;Department of Pathology,Liaoning Cancer Hospital&Institute,Shenyang 110042,Liaoning,China;Cancer Hospital,China Medical University,Shenyang 110042,Liaoning,China;Cancer Hospital,Dalian University of Technology,Shenyang 110042,Liaoning,China)

机构地区：[1]大连理工大学机械工程学院,辽宁大连116023 [2]之江实验室前沿基础研究中心,浙江杭州311121 [3]辽宁省肿瘤医院病理科,辽宁沈阳110042 [4]中国医科大学肿瘤医院,辽宁沈阳110042 [5]大连理工大学附属肿瘤医院,辽宁沈阳110042

出　　处：《中国激光》2024年第21期164-174,共11页Chinese Journal of Lasers

基　　金：国家自然科学基金(52175265,52275281)。

摘　　要：Mueller矩阵偏振成像方法相比于传统的非偏振光学探测手段更能展现生物组织丰富的微观结构信息,在生物组织病变检测方面具有巨大的应用潜力。本课题组以临床上容易误诊的乳腺硬化性腺病和早期浸润性导管癌组织为研究对象,采用Mueller矩阵极化分解和变换方法提取Mueller矩阵参数,利用最小包围球从分布范围的角度研究了Mueller矩阵参数在纤维化间质和细胞核区域对两种疾病差异的表征效果。研究结果显示:在纤维化间质区域,Mueller矩阵分解参数R以及R-θ-ψ、δ-θ-ψ、R-δ-ψ三种参数组合对两种疾病差异具有较好的表征效果,4种表征参数下的最小包围球相对半径差依次为68.77%、61.33%、61.09%和61.04%;在细胞核区域,Mueller矩阵分解参数Δ及Δ-δ-θ参数组合对两种疾病差异具有较好的表征效果,两种表征参数下的最小包围球相对半径差分别为57.36%和49.35%。结果表明,Mueller矩阵参数可用于对两种疾病差异的表征,为发展针对两种疾病的临床鉴别手段提供了参考。Objective Studies show that breast cancer ranks first among all cancers affecting women in China.Additionally,its mortality rate is high and continues to increase.The five-year relative survival rate of patients with breast cancer who are detected at an early stage is˃90%,whereas it is only 20%for those detected at an advanced stage.Therefore,early and effective diagnosis of breast cancer is crucial to patient recovery.Invasive ductal carcinoma is one of the most common types of breast cancer,and sclerosing adenopathy is a benign breast disease.These two diseases are similar both visually and microscopically and are susceptible to diagnostic errors.Immunohistochemical staining is typically required to identify these markers.It is a complicated and costly technique that can yield false-positive or false-negative results.Therefore,new methods for identifying sclerosing adenopathy and early invasive ductal carcinoma must be devised to reduce the misdiagnosis rates of both diseases.Polarimetric imaging can reflect the intricate microstructure of biological tissues and is promising for detecting biological tissues.Therefore,differential-tissue analysis for detecting sclerosing adenopathy and early invasive ductal carcinoma using polarization imaging methods is worth investigating.Methods Polarization imaging experiments were performed on sclerosing adenopathy and early invasive ductal carcinoma tissues.Subsequently,four vector parameters,i.e.,the delay vector(R),dichroic vector(D),polarization vector(P),and scattering receding vector(Δ);six scalar parameters,i.e.,the scattering receding matrix correlation parameter(Δ),phase-delay matrix correlation parameters(R,δ,θ,ψ),and dichroic correlation parameter(D)in the Mueller-matrix polarization decomposition(MMPD)method;and three scalar parameters(b,A,x)in the Mueller-matrix transformation(MMT)method were extracted.The vector parameters and the combination of scalar parameters were plotted in a three-dimensional(3D)scatter plot and a minimum enclosing sphere plot.The

关 键 词：生物医学 偏振成像探测 Mueller矩阵参数 硬化性腺病 浸润性导管癌 

分 类 号：O436.3[机械工程—光学工程]