基于柔性基底的表面增强拉曼光谱应用研究进展  

Recent Advances and Applications of Surface⁃Enhanced Raman Spectroscopy Technology Based on Flexible Substrates

作　　者：王楠 刘艺 张竣 何绍华 侯仕宏 冯尚源 林多 Wang Nan;Liu Yi;Zhang Jun;He Shaohua;Hou Shihong;Feng Shangyuan;Lin Duo(Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education,Key Laboratory of Photonic Technology of Fujian Province,College of Photonic and Electronic Engineering,Fujian Normal University,Fuzhou 350007,Fujian,China)

机构地区：[1]福建师范大学光电与信息工程学院,医学光电科学与技术教育部重点实验室,福建省光子技术重点实验室,福建福州350007

出　　处：《中国激光》2024年第21期217-233,共17页Chinese Journal of Lasers

基　　金：国家自然科学基金(12374405)。

摘　　要：表面增强拉曼光谱(SERS)技术是一种基于局域表面等离子共振的超灵敏光谱分析技术,在生物医学、食品安全、环境监测等方面均展现出了巨大的应用潜力。近年来,柔性SERS基底的发展受到了极大关注。柔性材料具有较好的柔韧性和可塑性,在面对各种复杂形状和不规则表面的应用场景时可以按需切割设计成任何所需的形状和尺寸,其结合高灵敏度的SERS技术在非破坏性和原位检测方面展现出了极大优势。本文综述了近年来基于柔性基底的SERS技术的研究进展,介绍了不同柔性材料构造SERS基底的常用方法以及柔性SERS基底在生物医学、食品安全、环境监测方面的最新应用,并对柔性SERS基底的发展进行了总结与展望。Significance Surface-enhanced Raman spectroscopy(SERS)is an optical sensing technology based on local surface plasmon resonance,which greatly enhances the Raman signal of molecules adsorbed or very close to the surface of rough nano-metals,even achieving single-molecule detection.The traditional SERS substrate is created by depositing precious metal nanoparticles(Ag,Au,Cu,etc.)on rigid substrates such as slides and silicon wafers.The preparation process of such substrates is relatively mature,offering good stability and sensitivity,and is widely used in molecular recognition,quantitative analysis,and other fields.However,complicated experimental pretreatment steps,high cost,high operational requirements,and fixed detection platform shapes limit the application range of SERS technology,making it unsuitable for sampling and detection of objects with complex shapes and irregular surfaces.To improve the flexibility and portability of detection,reduce costs and operational requirements,and broaden the application range of SERS technology,researchers have focused on developing new SERS substrates,with flexible SERS substrates attracting significant attention.Flexible substrates possess good flexibility and plasticity,and can be cut to any desired shape and size to accommodate various complex shapes and irregular surfaces,offering great advantages in non-destructive and in-situ detection.This review introduces the research progress in SERS technology based on flexible substrates in recent years.Firstly,different methods of constructing flexible SERS substrates using various flexible materials,including cellulose flexible substrates,polymer flexible substrates and other flexible materials,are discussed,highlighting the advantages and challenges of each.Additionally,the latest applications of flexible SERS substrates in biomedicine,food safety,and environmental monitoring are summarized.Progress First,based on the introduction of common materials for constructing flexible SERS substrates,including cellulose,polymer flexib

关 键 词：表面增强拉曼光谱 柔性SERS基底 生物医学 食品安全 环境监测 

分 类 号：O657.37[理学—分析化学]