Intratumor microbiota and colorectal cancer:Comprehensive and lucid review  

作　　者：Zhen Zong Wenjuan Zeng Yin Li Menghui Wang Yuke Cao Xifu Cheng Zhenhua Jin Shengxun Mao Xingen Zhu 

机构地区：[1]Department of Gastrointestinal Surgery,the Second Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,China [2]Huan Kui Academy,Jiangxi Medical College,Nanchang University,Nanchang 330006,China [3]School of Ophthalmology and Optometry,Jiangxi Medical College,Nanchang University,Nanchang 330006,China [4]Department of Neurosurgey,the Second Affiliated Hospital,Jiangxi Medical College,Nanchang University,Nanchang 330006,China [5]Jiangxi Province Key Laboratory of Neurological Diseases,Nanchang 330006,China [6]Institute of Neuroscience,Nanchang University,Nanchang 330006,China [7]Jiangxi Provincial Health Commission Key Laboratory of Neurological Medicine,Nanchang 330006,China

出　　处：《Chinese Journal of Cancer Research》2024年第6期683-699,共17页中国癌症研究(英文版)

基　　金：funded by the National Natural Science Foundation of China(No.82060453,82103645 and 82260596);the Natural Science Foundation of Jiangxi Province(No.20242BAB25506);the China Postdoctoral Science Foundation(No.2023M741523)。

摘　　要：As a key component of tumor microenvironment,the microbiota has gradually played a key role in cancer research.Particularly in colorectal cancer,the specific population of microbiota within the tumor shows a strong association with the tumor type.Although the existence and potential role of microbiota in tumors have been recognized,the specific associations between the microbiota and tumor tissue and the mechanism of action still need to be further explored.This paper reviews the discovery,origin,and emerging role of the intratumor microbiota in the immune microenvironment and systematically outlines the oncogenic and metastasis-promoting strategies of the intratumor microbiota.Moreover,it comprehensively and holistically evaluates therapeutic strategies and prognostic performance on the basis of the intratumor microbiota,with the goal of providing strong support for future research and clinical practice.

关 键 词：Intratumor microbiota colorectal cancer tumor microbiome cancer treatment 

分 类 号：R73[医药卫生—肿瘤]