间歇性外斜视患者术前特征对复发影响的Meta分析  

Risk factors of preoperative characteristics on postoperative recurrence of intermittent exotropia:a meta-analysis

作　　者：王子健 张璐 郭长梅 Wang Zi-jian;Zhang Lu;Guo Chang-mei(Department of Ophthalmology,Eye institute of Chinese PLA,Xijing Hospital,Air Force Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学西京医院眼科全军眼科研究所,710032 [2]延安大学医学院

出　　处：《中国斜视与小儿眼科杂志》2024年第4期1-5,I0004,共6页Chinese Journal of Strabismus & Pediatric Ophthalmology

基　　金：医务人员技术提升项目(2023XJSY29)。

摘　　要：目的评估间歇性外斜视(IXT)患者术后复发风险。探究复发的术前影响因素,为IXT患者手术时机选择、后续治疗方案提供参考。方法检索PubMed、Embase、The Cochrane Library、Web of Science、CNKI、VIP、WanFang Data数据库,时间限定为2000年1月至2024年3月,纳入报告IXT患者术后复发的基线相关影响因素的研究。合并OR、WMD及95%CI评估效应量对复发的影响。结果最终纳入18篇文献,共4074例患者,12项可能影响术后复发的因素。其中,手术年龄(WMD-0.88,P=0.005);发病年龄(WMD-0.80,P=0.02);术前斜视度(OR 1.05,P<0.00001);屈光参差(OR 2.17,P=0.04);远视(OR 3.21,P=0.0006)。结论手术年龄小、发病年龄早、术前斜视度大、屈光参差是IXT术后复发的风险因素。其次,术前融合功能、控制力、立体视、合并近视、合并垂直斜视、合并DVD、合并轻度弱视对IXT术后复发无显著影响。Objective To evaluate the risk of postoperative recurrence in patients with intermittent exotropia,and to provide reference for the choice of surgical timing and subsequent treatment of patients with intermittent exotropia.Methods The databases PubMed,Embase,the Cochrane Library,Web of Science,CNKI,VIP,and WanFang Data were systematically searched for studies published between January 2000 and March 2024.Included studies focused on identifying baseline factors associated with postoperative recurrence in patients with intermittent exotropia.Meta-analyses were conducted using pooled odds ratios(OR),weighted mean differences(WMD),and corresponding 95%confidence intervals(CI)to assess the magnitude of the effect size on recurrence.Results A total of 18 studies involving 4074patients were included,and 12 factors potentially influencing postoperative recurrence were identified.Age at surgery(WMD-0.88,P=0.005);Age of onset(WMD-0.80,P=0.02);Preoperative strabismus(OR 1.05,P<0.00001);Anisometropia(OR 2.17,P=0.04);Hyperopia(OR 3.21,P=0.0006).Conclusion Younger age at surgery,early onset age,larger preoperative angle and anisometropia are identified as risk factors for the recurrence of IXT following surgical intervention.Additionally,it was found that preoperative fusion function,control,stereopsis,myopia,vertical strabismus,and mild amblyopia do not have a statistically significant impact on the likelihood of IXT recurrence.

关 键 词：间歇性外斜视 复发 危险因素 

分 类 号：R73[医药卫生—肿瘤]