蓝光致视网膜损伤的研究进展  

Progress in the study of retinal damage caused by blue light

作　　者：张立平 彭春霞 蔺琪[1] 李莉[1] Zhang Li-ping;Peng Chun-xia;Lin Qi(Department of Ophthalmology,Beijing Children's Hospital,Capital Medical University,Key Laboratory of Major Diseases in Children,Ministry of Education,National Center for Children's Health,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京儿童医院眼科,儿科重大疾病研究教育部重点实验室,国家儿童医学中心,100045

出　　处：《中国斜视与小儿眼科杂志》2024年第4期42-44,I0005,共4页Chinese Journal of Strabismus & Pediatric Ophthalmology

基　　金：国家自然科学基金(82371093,81970844)。

摘　　要：在可见光中,短波长光(蓝光)的能量较高,过度暴露于蓝光(400~500nm)下会引起视网膜严重的光化学损伤,尤其是光感受器细胞和视网膜色素上皮细胞。关于蓝光对视网膜细胞损伤触发的通路和确切的信号机制仍尚未阐明。本文主要围绕视紫红质和脂褐素积累介导的视网膜细胞损伤以及视网膜细胞的死亡途径(依赖性细胞死亡、坏死性细胞凋亡、自噬、细胞凋亡及铁死亡)进行综述。Short wavelengths of light(blue light)have higher energies in the visible spectrum,and overexposure to blue light(400~500nm)causes severe photochemical damage to the retina,especially photoreceptor cells and retinal pigment epithelial cells.The exact signaling pathways and mechanisms triggering blue light damage to retinal cells have not yet been elucidated.This article focuses on retinal cell damage mediated by retinal pigment and lipofuscin accumulation as well as retinal cell death pathways(parthanatosis,necroptosis,autophagy,apoptosis,and ferroptosis).

关 键 词：蓝光 光感受器细胞 视网膜色素上皮细胞 视网膜光损伤 细胞死亡 

分 类 号：R73[医药卫生—肿瘤]