In vitro degradation and in vivo osteogenesis of Mg-Zn-Nd-Zr/HA composites prepared by friction stir processing  

作　　者：Wen Zhang Jiarui Lu Lili Tan Dingrui Ni Ran Zhang Qing Zhou Ke Yang Qiang Wang 

机构地区：[1]School of Materials Science and Engineering,University of Science and Technology of China,Shenyang 110016,China [2]Institute of Metal Research,Chinese Academy of Sciences,Shenyang 110016,China [3]Liaoning Provincial Key Laboratory of Oral Diseases,School and Hospital of Stomatology,China Medical University,Shenyang 110001,China

出　　处：《Journal of Magnesium and Alloys》2024年第12期4937-4952,共16页镁合金学报(英文)

基　　金：supported by The National Key Research and Development Program of China(No.2020YFC1107501);National Natural Science Foundation of China(No.51971222),STS program(No.20201600200042);Dong Guan Innovative Research Team Program.Basic applied research program of Liaoning Province of China(No.2022020347-JH2/1013)。

摘　　要：Biodegradable magnesium-matrix composites(BMMCs)added with bone-like compounds such as hydroxyapatite(HA)have promising orthopedic application potential,but the in vivo results of BMMCs are insufficient,and the difference between in vitro and in vivo are not clarified.In this work,Mg-Zn-Nd-Zr/(10/15/20wt%)HA(Ca_(10)(PO_(4))_(6)OH_(2))composites were prepared through friction stirring processing(FSP).It was found that corrosion rate of the composites increased with increase of the HA content,where the corrosion rate from hydrogen evolution of the Mg/10wt%HA was about 0.107 mm/y,showing better corrosion resistance compared with other BMMCs,and the agglomeration of HA powders significantly aggravated the localized corrosion.The ALP specific activity of the MC3T3-E1 cells cultured for14 days with Mg/10wt%HA(2.12 IU/mg)was higher than that of the matrix(1.85 IU/mg),but there was no difference with the FSP group(2.13 IU/mg).In the early implantation of the rabbit femur,bone volume fraction(BV/TV)of Mg/10wt%HA was 10.69,which was higher than that of the FSP group(6.35).The histological staining showed that the Mg/10wt%HA implant was surrounded by more trabecular bone tissue,exhibiting better osteoinductive regeneration.The Mg-Zn-Nd-Zr/HA composites exhibit higher osteogenic activity in vivo differently from in vitro osteogenic expression.

关 键 词：Biodegradable Mg-based composite Friction stir processing HYDROXYAPATITE OSTEOGENESIS In vivo biodegradation 

分 类 号：TB333[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]