基于Co-MOFs改性商业条形电极的葡萄糖传感器  

Glucose sensor based on Co-MOFs-modified commercial strip electrodes

作　　者：夏海艳 李佳楠 徐江红 张饶 全昌云 李苏原 XIA Haiyan;LI Jianan;XU Jianghong;ZHANG Rao;QUAN Changyun;LI Suyuan(Institute for Biosensors and Innovative Materials,Cofoe Medical Technology Co.,Ltd.,Changsha 410000,China;College of Physical Science and Technology,Lingnan Normal University,Zhanjiang 524048,China;College of Science,Yanshan University,Qinhuangdao 066004,China;Institute of New Energy,Hexi University,Zhangye 734000,China)

机构地区：[1]可孚医疗科技股份有限公司生物传感器与创新材料研究院,长沙410000 [2]岭南师范大学物理科学与技术学院,湛江524048 [3]燕山大学理学院,秦皇岛066004 [4]河西学院新能源研究所,张掖734000

出　　处：《复合材料学报》2024年第12期6580-6588,共9页Acta Materiae Compositae Sinica

基　　金：河西学院博士启动基金(KYQD2022006);湛江市科技计划(2023B01001)。

摘　　要：第三代葡萄糖传感器中氧化酶存在容易受温度、湿度、酸碱度等影响的缺点。因此,开发低成本、高灵敏度的葡萄糖催化剂具有广阔的应用前景。金属-有机框架(Metal-origanic frameworks,MOFs)因具有传质速度快、孔隙率可调和电子转移能力强等优点而受到广泛的关注。丝网印刷技术是一种低成本、批量化制备商业电极工艺。本文采用一种简单、经济的方法室温下成功地合成了Co-MOFs,采用丝网印刷技术将Co-MOFs涂敷在商业化条形银-碳电极上。作为生物传感器的催化剂,Co-MOFs纳米材料对葡萄糖表现出较高的电催化活性。测试结果表明,Co-MOFs基条形电极对葡萄糖检测的灵敏度为1393 nA·L/(mmol·cm^(2)),检测极限为0.58μmol/L(S/N=3),线性范围为0.1~0.5 mmol/L。该工作对葡萄糖传感器中批量构筑多功能电极的设计具有一定的指导意义。The oxidase catalyst in the third-generation glucose sensors can be easily affected by temperature,humidity,and pH.As a result,developing some catalysts with low cost and high sensitivity has a broad application prospect.Metal-organic frameworks(MOFs)have attracted much attention because of their high mass transfer rate,adjustable porosity and strong electron transfer ability.The screen-printing technique has been used to fabricate commercial electrodes due to its low cost and batch preparation.Here,Co-MOFs were successfully synthesized by a simple and economical method at room temperature and coated on commercial strip silver-carbon electrode by screen-printing technique.As a biosensor catalyst,Co-MOFs nanomaterials exhibit high electrocatalytic activity for glucose.The results showed that the sensitivity of Co-MOFs-based strip electrode for glucose detection was 1393 nA·L/(mmol·cm^(2)).The detection limit was 0.58μmol/L(S/N=3)and the linear range was 0.1-0.5 mmol/L.This work has certain guiding significance for the design of multi-function electrode in glucose sensor.

关 键 词：电化学传感器 葡萄糖检测 Co-MOFs 丝网印刷 金属-有机框架 

分 类 号：TB333[一般工业技术—材料科学与工程] TS207.3[轻工技术与工程—食品科学] O614.121[轻工技术与工程—食品科学与工程]