维生素D辅助微生态制剂、美沙拉嗪治疗溃疡性结肠炎的效果研究  

Efficacy of vitamin D-assisted microecological preparations and mesalazine in treatment of ulcerative colitis(UC)

作　　者：杨静芳 王彬彬 石向阳[1] YANG Jingfang;WANG Binbin;SHI Xiangyang(Department of Gastroenterology,Chizhou People's Hospital,Chizhou Anhui 247000,China)

机构地区：[1]池州市人民医院消化内科,安徽池州247000

出　　处：《新疆医科大学学报》2025年第1期60-65,共6页Journal of Xinjiang Medical University

基　　金：安徽省卫生健康科研基金项目(2021D027)。

摘　　要：目的研究维生素D辅助微生态制剂、美沙拉嗪治疗溃疡性结肠炎(Ulcerative colitis,UC)的效果。方法以2021年1月-2023年12月池州市人民医院消化内科收治的94例UC患者为研究对象,随机分组为研究组和对照组,每组47例。对照组(双歧杆菌乳杆菌三联活菌胶囊+美沙拉嗪,口服,持续治疗1个月),研究组(双歧杆菌乳杆菌三联活菌胶囊+美沙拉嗪+维生素D,口服,持续治疗1个月),治疗前/后(结束治疗次日)采血,采用酶标法测量患者血清炎性因子、肠道屏障功能指标,采用流式细胞仪测量患者T淋巴细胞,进行肠镜检查及病理活检,评估其临床症状[改良梅奥(Mayo)评分]、病理组织学情况(Robarts病理组织学指数)、肠内镜下表现[内镜下严重程度指数(Ulcerative colitis endoscopic index of severity,UCEIS)评分]及临床疗效,记录皮肤症状、胃肠道不适等不良反应。结果治疗后两组患者血清C-反应蛋白(C-reactive protein,CRP)、白介素(Interlukin,IL)-8水平上升,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗后两组患者CD3^(+)、CD4^(+)T细胞上升,且研究组高于对照组,CD8^(+)T细胞均下降,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗后两组患者血清D-乳酸(D-lactic acid,D-LA)及二胺氧化酶(Diamine oxidase,DAO)水平均下降,且研究组低于对照组,差异均有统计学意义(P<0.05)。治疗后两组患者UCEIS、改良梅奥(Mayo)评分均下降,且研究组低于对照组,差异均有统计学意义(P<0.05);治疗后两组患者Robarts病理组织学指数评分均降低,且研究组低于对照组,差异均有统计学意义(P<0.05)。与对照组比较,研究组总有效率升高,差异有统计学意义(P<0.05);研究组神经系统症状、皮肤症状、胃肠道不适及不良反应总发生率比较,差异无统计学意义(P>0.05),结论维生素D辅助微生态制剂、美沙拉嗪治疗溃UC,可改善患者炎症反应、肠道屏障功能及�Objective To study the effect of vitamin D-assisted proecological preparations and mesalazine in the treatment of ulcerative colitis(UC).Methods A total of 94 patients with UC admitted to the hospital from January 2021 to December 2023 were selected as research subjects and randomly divided into a re-search group and a control group,with 47 cases in each group.The control group(Bifidobacterium-Lacto-bacillus triple live capsules+mesalazine,oral,continuous treatment for 1 month)and the study group(Bifidobacterium-Lactobacillus triple live capsules+mesalazine+vitamin D,oral,continuous treatment for 1 month)had blood drawn before and after the treatment(the day after the end of treatment).The serum inflammatory factors and intestinal barrier function indexes of the patients were measured by enzyme la-beled method,and the T lymphocytes of the patients were measured by flow cytometry.Colonoscopy and pathological biopsy were performed to evaluate their clinical symptoms(modified Mayo score),his-topathological conditions(Robarts histopathological index score),endoscopic manifestations[Ulcerative colitis endoscopic index of severity(UCEIS)score]and clinical efficacy and adverse reactions such as skin symptoms and gastrointestinal discomfort were recorded.Results After thetreatment,the levels of serum C-reactive protein(CRP)and interleukin(IL)-8 in the 2 groups of patients were increased,and the levels in the study group were lower than those in the control group,with significant differences(P<0.05).After the treatment,the levels of CD3^(+) and CD4^(+)T cells in the 2 groups of the patients were increased,and the levels in the study group were higher than those in the control group,while the levels of CD8^(+)T cells weredecreased,and the levels in the study group were lower than those in the control group,with significant differences(P<0.05).After the treatment,the levels of serum d-lactic acid(D-LA)and di-amine oxidase(DAO)in both groups of the patients were decreased,and the levels in the study group were lower than tho

关 键 词：维生素D 溃疡性结肠炎 美沙拉嗪 微生态制剂 随机对照 

分 类 号：R574.1[医药卫生—消化系统]