非小细胞肺癌组织病理特征与临床预后、基因组突变谱的关联研究  

Correlation studies of histopathological features,clinical prognosis,and genomic mutation profiles in non-small cell lung cancer

作　　者：何璐 李志文[1] 孟凡青[1] 汪亦品[2] He Lu;Li Zhiwen;Meng Fanqing;Wang Yipin(Department of Pathology,The Affiliated Hospital of Nanjing University Medical School/Nanjing Trum Tower Hospital,Nanjing 210008,China;National Demonstration Center for Experimental Basic Medical Education,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]南京大学医学院附属鼓楼医院病理科,南京210008 [2]南京医科大学基础医学国家级实验教学示范中心,南京211166

出　　处：《临床与实验病理学杂志》2025年第1期99-104,共6页Chinese Journal of Clinical and Experimental Pathology

摘　　要：肺癌是全球高发恶性肿瘤之一,亟需更多的临床标志物以指导精准分层治疗,提高生存率。既往大量研究着眼于非小细胞肺癌(non-small cell lung cancer, NSCLC)的组织病理学特征与驱动基因突变及预后的关联性,以期从形态学角度预测患者潜在的分子学背景、治疗效果和可能的临床转归。该文旨在简述NSCLC预后相关的一系列新兴组织病理学指标的研究进展,并讨论其对NSCLC预后的指导意义。Lung cancer represents as one of the most prevalent malignant tumors globally,necessitating the urgent identification of additional biomarkers to facilitate precise stratified treatment and elevate its survival rates.Previous studies have focused on the correlation between the histopathological characteristics,driver gene mutations,and prognosis of non-small cell lung cancer(NSCLC),with the aim of predicting the potential molecular background,treatment efficacy,and possible clinical outcomes of patients from the morphological perspective.This article aims to briefly summarize the advancements in emerging histopathological indicators of NSCLC,and discuss their implications for guiding the prognosis of this disease.

关 键 词：非小细胞肺癌 沿气腔内播散 肿瘤出芽 IASLC分级 驱动基因突变 文献综述 

分 类 号：R734.2[医药卫生—肿瘤]