微孢子虫分泌蛋白研究进展  

Advances on Secretory Proteins in Microsporidia

作　　者：冉茂双 曹露[1,2] 杨雯馨 尹思英 李田[1,2] 潘国庆[1,2] 周泽扬[1,2,3] 包佳玲 RAN Maoshuang;CAO Lu;YANG Wenxin;YIN Siying;LI Tian;PAN Guoqing;ZHOU Zeyang;BAO Jialing(The State Key Laboratory of Resource Insects,Southwest University,Chongqing 400715,China;Chongqing Key Laboratory of Microsporidia Infection and Control,Southwest University,Chongqing 400715,China;College of Life Science,Chongqing Normal University,Chongqing 401331,China)

机构地区：[1]资源昆虫高效养殖与利用全国重点实验室(西南大学),重庆400715 [2]西南大学微孢子虫感染与防控重庆市重点实验室,重庆400715 [3]重庆师范大学生命科学学院,重庆401331

出　　处：《蚕学通讯》2024年第4期32-41,共10页Newsletter of Sericultural Science

基　　金：国家自然科学基金项目(31802141);重庆市自然科学基金创新群体项目(cstc2021jcyj-cxtt0005);中央高校基本科研业务费项目(XDJK2020B005,SWU-XDJH202322)。

摘　　要：微孢子虫是一类单细胞真核病原体,其宿主范围极其广泛。微孢子虫依赖宿主细胞完成其增殖周期,在宿主细胞内可分泌相关的蛋白质,通过分泌蛋白的功能与宿主细胞互作、调控并达到顺利存活及增殖的目的。本文首先从微孢子虫的基因组水平分析了微孢子虫分泌蛋白的种类及表达特征等,接着从分泌蛋白的功能、作用、鉴定方法等方面,详细探讨了微孢子虫的分泌蛋白在对宿主细胞侵袭和在宿主细胞内增殖过程中起到的关键性作用。微孢子虫分泌蛋白的最新研究成果不仅有助于阐明病原操纵宿主的分子机制,也有助于为抗寄生虫治疗提供潜在靶点。Microsporidia are a group of single-celled eukaryotic parasite College of Life Science,Chongqing Normal University,Chongqing 401331,China s with an extremely broad host range.They rely on completing their proliferation cycle within host cells,where they can secrete related proteins.These secreted proteins interact with and regulate host cells to ensure their own survival and proliferation.This article first analyzes the types and expression characteristics of secreted proteins in various microsporidia at the genomic level,and then delves into the functions,roles,and identification methods of these secreted proteins,detailing their key roles in the process from host cell invasion to intracellular proliferation.The latest research progress on secreted proteins not only helps to elucidate the molecular mechanisms by which pathogens manipulate hosts but also provides potential targets for antiparasitic treatment.

关 键 词：微孢子虫 基因组 分泌蛋白 病原与宿主互作 

分 类 号：R73[医药卫生—肿瘤]