基于网络药理学及分子对接技术分析四逆汤防治畜禽腹泻作用的机制  

Mechanism of Sini Decoction in Preventing and Treating Livestock and Poultry Diarrhea Based on Network Pharmacology Analysis and Molecular Docking Technology

作　　者：田甜 孙宏鑫 王春花 TIAN Tian;SUN Hong-xin;WANG Chun-hua(Mudanjiang Normal University,College of life science and technology,Mudanjiang,Heilongjang 157000,China)

机构地区：[1]牡丹江师范学院生命科学与技术学院,黑龙江牡丹江157000

出　　处：《中国兽药杂志》2025年第1期36-45,共10页Chinese Journal of Veterinary Drug

基　　金：黑龙江省省属本科高校基本科研业务费项目(1453CXY06);黑龙江省自然科学基金(LH2021C096);黑龙江省博士后基金(LBH-Z21102)。

摘　　要：基于网络药理学和分子对接技术分析四逆汤的有效成分及其防治畜禽腹泻的作用机制,预测四逆汤组方中药干姜,附子,甘草的有效成分、作用靶点、靶点与腹泻靶点关系以及富集的通路。结果显示四逆汤可能通过美迪紫檀素、甘草酚、柚皮素、山奈酚、槲皮素等潜在活性成分,作用TP53、AKT1、STAT3等靶点,通过干预AGE-RACE,IL-17,TNF等抗炎相关通路在畜禽机体中发挥抗腹泻作用。Based on network pharmacology and molecular docking technology,the effective components of Sini Decoction and its mechanism of prevention and treatment of animal diarrhea were analyzed,and the effective components,action targets,the relationship between targets and diarrhea targets and enrichment pathways of Sini Decoction were predicted.The results showed that Sini decoction may act on TP53,AKT1,STAT3 and other targets through potential active ingredients such as Medilac,glycyrrhizin,naringenin,kaempferol and quercetin,and play an anti diarrhea effect in livestock and poultry by interfering with anti-inflammatory related pathways such as age-race,IL-17 and TNF.

关 键 词：四逆汤 腹泻 分子对接 网络药理学 

分 类 号：S859.79[农业科学—临床兽医学]