PCT、TNF-α、IL-1β水平联合检测在胆囊切除术后患者胆道感染诊断中的效能  

Efficiency of combined detection of PCT,TNF-αand IL-1βlevels in diagnosis of biliary tract infection in patients after cholecystectomy

作　　者：刘东升 LIU Dongsheng(First Department of Surgery of Henan No.3 Provincial People’s Hospital,Zhengzhou 450000 Henan,China)

机构地区：[1]河南省直第三人民医院外一科,河南郑州450000

出　　处：《中国民康医学》2025年第3期132-134,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:分析降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平联合检测在胆囊切除术后患者胆道感染诊断中的效能。方法:选取2021年6月至2023年6月于该院行胆囊切除术的80例患者为观察组,另选取同期该院80名健康体检者为对照组。比较两组、发生胆道感染与未发生胆道感染患者PCT、TNF-α、IL-1β水平,并绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),分析PCT、TNF-α、IL-1β水平单项及联合检测在胆囊切除术后患者胆道感染诊断中的效能。结果:观察组PCT、TNF-α、IL-1β水平均高于对照组,差异有统计学意义(P<0.05);发生胆道感染患者PCT、TNF-α、IL-1β水平均高于未发生胆道感染患者,差异有统计学意义(P<0.05);PCT、TNF-α、IL-1β水平单项及联合检测诊断胆囊切除术后患者胆道感染的AUC分别为0.815、0.833、0.780、0.994,其中联合检测的AUC高于三者单项检测。结论:PCT、TNF-α、IL-1β水平联合检测诊断胆囊切除术后患者胆道感染的效能高于三者单项检测。Objective:To observe efficiency of combined detection of procalcitonin(PCT),tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)levels in diagnosis of biliary tract infection in patients after cholecystectomy.Methods:A total of 80 patients who underwent cholecystectomy in this hospital from June 2021 to June 2023 were selected as the observation group,and 80 healthy subjects in this hospital during the same period were selected as the control group.The levels of PCT,TNF-αand IL-1βwere compared between the two groups and between the patients with biliary tract infection and without biliary tract infection.The receiver operating characteristic(ROC)curve was drawn and the area under the curve(AUC)was calculated.The efficiency of single and combined detection of PCT,TNF-αand IL-1βlevels in the diagnosis of biliary tract infection in the patients after cholecystectomy were analyzed.Results:The levels of PCT,TNF-αand IL-1βin the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of PCT,TNF-αand IL-1βin the patients with biliary tract infection were higher than those in the patients without biliary tract infection,and the differences were statistically significant(P<0.05).The AUC of single and combined detection of PCT,TNF-αand IL-1βlevels in the diagnosis of biliary tract infection in the patients after cholecystectomy were 0.815,0.833,0.780 and 0.994,separately.The AUC of combined detection was higher than that of single detection.Conclusions:The efficiency of combined detection of PCT,TNF-αand IL-1βlevels in the diagnosis of biliary tract infection in the patients after cholecystectomy is higher than that of the three single tests.

关 键 词：胆囊切除术 胆道感染 降钙素原 肿瘤坏死因子-α 白细胞介素-1Β 诊断 

分 类 号：R575[医药卫生—消化系统]