全子宫加双附件切除术与广泛性子宫切除术治疗子宫内膜癌患者的效果比较  

Comparison of effects of total hysterectomy plus bilateral adnexectomy and extensive hysterectomy in treatment of patients with endometrial carcinoma

作　　者：郭灵芝 GUO Lingzhi(Department of Gynecology of Zhoukou First People’s Hospital,Zhoukou 466700 Henan,China)

机构地区：[1]周口市第一人民医院妇科,河南周口466700

出　　处：《中国民康医学》2025年第3期161-163,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较全子宫加双附件切除术与广泛性子宫切除术治疗子宫内膜癌患者的效果。方法:回顾性分析2019年8月至2023年8月该院收治的64例子宫内膜癌患者的临床资料,按手术方案不同将其分为对照组与研究组各32例。研究组采用全子宫加双附件切除术治疗,对照组采用广泛性子宫切除术治疗。比较手术相关指标(手术时间、住院时间、术中出血量)水平,手术前后肿瘤标志物[人人表皮生长因子受体2(HER2)、糖类抗原125(CA125)、癌胚抗原(CEA)]、炎性因子[白细胞介素(IL)-1、IL-9、IL-17]水平,以及并发症发生率和复发率。结果:研究组手术时间、住院时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05);术后1个月,两组HER2、CA125、CEA水平均低于术前,但组间比较,差异无统计学意义(P>0.05);术后1 d,两组IL-1、IL-9、IL-17水平均高于术前,但研究组低于对照组,差异有统计学意义(P<0.05);研究组并发症发生率为3.13%,低于对照组的25.00%,差异有统计学意义(P<0.05);两组复发率比较,差异无统计学意义(P>0.05)。结论:全子宫加双附件切除术治疗子宫内膜癌患者可缩短康复进程,降低炎性因子水平和并发症发生率的效果优于广泛性子宫切除术治疗。Objective:To compare effects of total hysterectomy plus double adnexectomy and extensive hysterectomy in treatment of patients with endometrial carcinoma.Methods:The clinical data of 64 patients with endometrial carcinoma admitted to the hospital from August 2019 to August 2023 were retrospectively analyzed.According to different surgical schemes,they were divided into control group and study group,32 cases in each group.The study group was treated with total hysterectomy and bilateral adnexectomy,while the control group was treated with extensive hysterectomy.The levels of operation-related indicators(operation time,hospitalization time,intraoperative blood loss),tumor markers[human epidermal growth factor receptor 2(HER2),carbohydrate antigen 125(CA125),carcinoembryonic antigen(CEA)]and inflammatory factors[interleukin(IL)-1,IL-9,IL-17]before and after the surgery,the incidence of complications,and the recurrence rate were compared between the two groups.Results:The operation time and the hospitalization time of the study group were shorter than those of the control group,the intraoperative blood loss was less than that of the control group,and the differences were statistically significant(P<0.05).One month after the surgery,the levels of HER2,CA125,and CEA in both groups were lower than those before the surgery,but there were no statistically significant differences between the groups(P>0.05).One day after the surgery,the levels of IL-1,IL-9 and IL-17 in the two groups were higher than those before the surgery,but those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of complications in the study group was 3.13%,which was lower than 25.00%in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the recurrence rate between the two groups(P>0.05).Conclusions:Total hysterectomy plus bilateral adnexectomy for the patients with endometrial carcinoma can shorten the rehabili

关 键 词：全子宫加双附件切除术 广泛性子宫切除术 子宫内膜癌 肿瘤标志物 炎性因子 并发症 

分 类 号：R737.33[医药卫生—肿瘤]