DNA损伤应答关键蛋白对肿瘤放疗敏感性影响的研究进展  

Research progress on impact of key proteins associated with DNA damage response on radiosensitivity

作　　者：黄绍荣 方连英 孙昊 郑林萍 陈英民 李卫国 马娅 HUANG Shaorong;FANG Lianying;SUN Hao;ZHENG Linping;CHEN Yingmin;LI Weiguo;MA Ya(School of Preventive Medicine Sciences(Institute of Radiation Medicine),Shandong First Medical University(Shandong Academy of Medical Sciences),Jinan 250117 China;School of Public Health,Shandong First Medical University(Shandong Academy of Medical Sciences),Jinan 250117 China)

机构地区：[1]山东第一医科大学(山东省医学科学院)预防医学科学学院(放射医学研究所),山东济南250117 [2]山东第一医科大学(山东省医学科学院)公共卫生与健康管理学院,山东济南250117

出　　处：《中国辐射卫生》2024年第6期716-721,共6页Chinese Journal of Radiological Health

基　　金：国家自然科学基金(32100999);山东省自然科学基金(ZR2020QC082);山东省医药卫生科技发展计划项目(202202080554);山东省医学科学院放射医学研究所发展基金(2023-1)。

摘　　要：目前肿瘤的发生率和死亡率日趋增加,肿瘤的治疗问题也备受关注。放疗作为肿瘤治疗的重要手段之一,但其治疗的有效性仍受到放射抗性的限制。在肿瘤放疗过程中,DNA损伤应答(DDR)是肿瘤细胞表现出放射抗性的关键因素。研究发现,通过调控DDR途径关键蛋白的表达,能够有效提升肿瘤细胞的放疗敏感性。针对DDR信号通路的靶向策略已经成为降低肿瘤放射抗性的一种有效途径。本文重点介绍了DDR关键蛋白DNA-PKcs、ATM、ATR和PARP作为治疗靶点在肿瘤放疗增敏中的作用机制、临床研究现状、局限性以及当前面临的挑战,以期为放疗增敏剂的研发提供相关参考。At present,the incidence and mortality of tumors are increasing,and the treatment of tumors has attracted much attention.Radiotherapy is a key method for tumor treatment;however,its effectiveness is often constrained by radioresistance.During tumor radiotherapy,DNA damage response(DDR)is a key factor in the radioresistance of tumor cells.Research has shown that the radiosensitivity of tumor cells can be effectively improved by regulating the expression of key proteins in the DDR pathway.Targeting the DDR signaling pathway has become an effective strategy to reduce tumor radioresistance.This article focuses on the mechanisms,clinical research status,limitations,and current challenges associated with the key DDR proteins DNA-PKcs,ATM,ATR,and PARP as therapeutic targets for tumor radiotherapy sensitization,in order to provide a reference for the development of radiotherapy sensitization agents.

关 键 词：放射敏感性 放射治疗 DNA损伤应答 DNA损伤修复 

分 类 号：R730[医药卫生—肿瘤]