基于中西医临床病症特点的急性阑尾炎动物模型分析  

Analysis of Animal Models of Acute Appendicitis Based on Clinical Symptoms of Traditional Chinese and Western Medicine

作　　者：南硕 宫欢欢 张媛鑫 李秀敏 苗明三[1] NAN Shuo;GONG Huanhuan;ZHANG Yuanxin;LI Xiumin;MIAO Mingsan(Academy of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,郑州450046

出　　处：《世界科学技术-中医药现代化》2024年第12期3234-3239,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会重大课题(82274119):基于“组分-性-效”论的鲜小蓟治疗慢性肾炎的分子机制,负责人:苗明三;河南省科学技术厅重大公益专项(201300310100):豫产道地中药材资源综合利用中心,负责人:苗明三;国家中医药管理局科研型项目(国中医药人教函2022-6):负责人:苗明三。

摘　　要：目的急性阑尾炎是一种临床常见急症,中医治疗阑尾炎起步早发展缓慢,如今临床多以切除阑尾治疗,为促进中医药继承与发展,故本文归纳总结急性阑尾炎动物模型,进行临床吻合度评价,并提出完善建议。方法通过搜索知网、万方、维普及Pubmed等数据库,归纳总结急性阑尾炎动物模型,对各模型赋值并进行临床吻合度评价。结果结扎阑尾及动静脉、结扎阑尾、结扎阑尾并穿孔、注射细菌、注射盐酸5种模型吻合度均较高,但从临床发病机理及综合考虑各造模条件来说,结扎阑尾应用较多。结扎阑尾、注射细菌及注射盐酸可用于药效机制研究,但注射细菌、盐酸与临床发病机理相差较大,结扎阑尾及动静脉、结扎阑尾并穿孔不宜用于药效研究。5种造模方法多以西医造模方法为主,基本未涉及中医证型。结论在5种造模方法基础上,予以中医瘀滞证、湿热证、热毒证因素干预,可制备体现中医证型的病证结合模型,以具备中医证型的动物模型为载体,更有利于中医药的研究及发展。Objective Acute appendicitis is a common clinical emergency.In traditional Chinese medicine,the famous Fang Dahuang Mudan Decoction has been recorded for the treatment of appendicitis.Therefore,this paper summarizes the animal models of acute appendicitis,evaluates the clinical consistency,and puts forward suggestions for improvement.Methods By searching databases such as CNKI,Wanfang and Pubmed,the animal models of acute appendicitis were summarized,assigned to each model and evaluated for clinical fit.Results The five models of appendix and arteriovenous ligation,appendix ligation,appendix ligation and perforation,bacteria injection,and hydrochloric acid injection were all highly consistent.Most of the five modeling methods are based on Western medicine modeling methods,and basically do not involve TCM syndrome types.Conclusion On the basis of five modeling methods,with the intervention of TCM stasis syndrome,damp-heat syndrome,and heat-toxin syndrome factors,an integrated TCM and Western medicine model that reflects TCM syndrome types can be prepared.Taking animal models with TCM syndromes as a carrier is more conducive to the research and development of TCM.

关 键 词：急性阑尾炎 动物模型 中西医 临床特点 

分 类 号：R-332[医药卫生]