基于中西医临床病证特点的风湿性心脏病动物模型特点分析  

Analysis of the Characteristics of Animal Models of Rheumatic Heart Disease Based on the Characteristics of Clinical Symptoms of Traditional Chinese and Western Medicine

作　　者：岳璐 王琨 苗明三[1] 白明[1] YUE Lu;WANG Kun;MIAO Mingsan;BAI Ming(Henan University of Chinese Medicine,Henan Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学豫药全产业链研发河南省协同创新中心,郑州450046

出　　处：《世界科学技术-中医药现代化》2024年第12期3240-3245,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会重大课题(82274119):基于“组分-性-效”论的鲜小蓟治疗慢性肾炎的分子机制,负责人:苗明三;河南省科学技术厅重大公益专项(201300310100):豫产道地中药材资源综合利用研究,负责人:苗明三;国家中医药管理局岐黄学者支持项目(国中医药人教函2022-6):负责人:苗明三。

摘　　要：目的基于中西医临床病证特点,对现有的风湿性心脏病(RHD)模型进行总结,并从其优缺点方面进行分析,系统评价模型与临床的吻合度。方法通过总结现有的RHD动物模型中西医病因病机及相关检测指标,分析模型优缺点并在中西医临床病证特点的基础上进行吻合度分析。结果对现有的国内外文献汇总分析结果显示,RHD动物模型制备方法有A组乙型溶血性链球菌(GAS)未灭活诱导法、GAS-M蛋白诱导法和GAS灭活诱导法三大类;其中,以GAS未灭活静脉注射法的西医临床吻合度最高,与RHD的临床指标,超声心动图及病理指标等比较符合,具有参考意义。但现有RHD动物模型中医吻合度普遍较低,缺乏中医干扰因素及评价体系,且模型评价多以西医病理及实验室检测指标作为依据,缺少对表观指标的记录,具有一定的局限性。结论RHD动物模型可以中医病机为依据,增加对动物表观行为的观察,提高对中医四诊及证候的体现,建立更加完善的具有中西医临床病证特点的RHD动物模型。Objective Based on the clinical characteristics of traditional Chinese and Western medicine,this paper summarizes the existing models of rheumatic heart disease(RHD),analyzes their advantages and disadvantages,and systematically evaluates the compatibility between the models and clinical practice.Methods By summarizing the etiology,pathogenesis,and related detection indicators of existing RHD animal models in traditional Chinese and Western medicine,analyzing the advantages and disadvantages of the models,and conducting a consistency analysis based on the clinical characteristics of traditional Chinese and Western medicine.Results The summary analysis of existing domestic and foreign literature shows that there are three main methods for preparing RHD animal models:GAS-M protein induction,GAS inactivation induction,and GAS inactivation induction;Among them,the Western medicine clinical fit of GAS inactivated intravenous injection method is the highest,which is consistent with the clinical indicators,echocardiography,and pathological indicators of RHD,and has reference significance.However,the existing RHD animal models generally have a low degree of conformity with traditional Chinese medicine,lack interference factors and evaluation systems in traditional Chinese medicine,and the model evaluation is mostly based on Western medicine pathology and laboratory testing indicators,lacking records of epigenetic indicators,which has certain limitations.Conclusion The RHD animal model can be based on the pathogenesis of traditional Chinese medicine,increase the observation of animal epigenetic behavior,improve the reflection of the four diagnostic methods and syndromes of traditional Chinese medicine,and establish a more comprehensive RHD animal model with clinical characteristics of traditional Chinese and Western medicine.

关 键 词：风湿热 风湿性心脏病 病证特点 动物模型 

分 类 号：R-058[医药卫生]