Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases  

作　　者：Renpeng Zhou Weirong Hu Peter X.Ma Chuan-ju Liu 

机构地区：[1]Department of Orthopaedics and Rehabilitation,Yale University School of Medicine,New Haven,CT,USA [2]Department of Biologic and Materials Sciences and Prosthodontics,School of Dentistry,University of Michigan,Ann Arbor,MI,USA

出　　处：《Bone Research》2024年第4期745-765,共21页骨研究(英文版)

基　　金：supported by NIH research grants R01AR062207,R01AR061484,R01AR076900,R01AR078035,and R01NS070328。

摘　　要：Bone and joint-related diseases,including osteoarthritis(OA),rheumatoid arthritis(RA),and bone tumors,pose significant health challenges due to their debilitating effects on the musculoskeletal system.14-3-3 proteins,a family of conserved regulatory molecules,play a critical role in the pathology of these diseases.This review discusses the intricate structure and multifunctionality of 14-3-3 proteins,their regulation of signaling pathways,and their interactions with other proteins.We underscore the significance of 14-3-3 proteins in the regulation of osteoblasts,osteoclasts,chondrocytes,and bone remodeling,all key factors in the maintenance and dysfunction of bone and joint systems.Specific focus is directed toward elucidating the contribution of 14-3-3proteins in the pathology of OA,RA,and bone malignancies,where dysregulated 14-3-3-mediated signaling cascades have been implicated in the disease processes.This review illuminates how the perturbation of 14-3-3 protein interactions can lead to the pathological manifestations observed in these disorders,including joint destruction and osteolytic activity.We highlight cuttingedge research that positions 14-3-3 proteins as potential biomarkers for disease progression and as innovative therapeutic targets,offering new avenues for disease intervention and management.

关 键 词：DISEASES offering DATING 

分 类 号：R68[医药卫生—骨科学]