Sirtuins在骨质疏松症中的研究进展  

Research progress of Sirtuins in osteoporosis

作　　者：吴火峰 张亮 李争光[2] 宰爽嘉 孙华 张永博 陈浏阳 戴睿 WU Huo-feng;ZHANG Liang;LI Zheng-guang;ZAI Shuang-jia;SUN Hua;ZHANG Yong-bo;CHEN Liu-yang;DAI Rui(Northern Jiangsu People's Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu 225001,China;Orthopedics,Northern Jiangsu People's Hospital,Yangzhou 225001,Jiangsu,China)

机构地区：[1]扬州大学附属苏北人民医院骨科,江苏扬州225001 [2]江苏省苏北人民医院骨科,江苏扬州225001

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2024年第6期631-637,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金面上项目(82172462);江苏省中医药科技发展计划项目(YB2020085);江苏省苏北人民医院院级科研基金(交叉合作专项)(SBJC21014);江苏省第六期“333工程”优秀青年人才科研项目(苏人才办[2022]21号);扬州市重点研发项目(社会发展)(YZ2021083)。

摘　　要：Sirtuins 1-7(SIRT1-SIRT7)是烟酰胺腺嘌呤二核苷酸依赖性去乙酰化酶家族,具有促进长寿和延缓年龄相关疾病的作用。Sirtuins通过对骨细胞的直接作用在正常的骨骼发育和体内平衡中发挥关键作用。SIRT1可以调节破骨细胞活性、促进间充质干细胞的成骨分化和骨矿化,并可以通过调节线粒体稳态从而调控骨形成和骨吸收中的骨稳态。SIRT3可以通过调节线粒体功能来调控成骨细胞分化和间充质干细胞衰老;SIRT6则可以诱导破骨细胞凋亡及促进成骨细胞活性,并且通过维持线粒体稳态来改善间充质干细胞衰老和成骨分化;而SIRT7在调控间充质干细胞成骨分化也发挥重要作用。因此Sirtuins可能是调节骨重塑和治疗骨质疏松症的潜在靶标。Sirtuins 1-7(SIRT1-SIRT7)are a family of nicotinamide adenine dinucleotide-dependent deacetylases that have the ability to promote longevity and fight age-related diseases.Sirtuins play a key role in normal bone development and homeostasis through their direct action on bone cells,and their disorder may lead to an imbalance in bone homeostasis leading to osteoporosis.SIRT1 regulates osteoclast activity,osteogenic differentiation of mesenchymal stem cells,and bone mineralization,and maintains bone homeostasis in bone formation and bone resorption by regulating mitochondrial homeostasis.SIRT3 can regulate mitochondrial function to regulate osteoblast differentiation and mesenchymal stem cell aging.SIRT6 can induce osteoclast apoptosis,promote osteoblast activity and maintain mitochondrial homeostasis to improve mesenchymal stem cell aging and osteogenic differentiation.SIRT7 also plays an important role in regulating mesenchymal stem cell osteogenic differentiation.Therefore,Sirtuins may be potential targets for regulating bone remodeling and treating osteoporosis.

关 键 词：SIRTUINS 骨质疏松症 骨重塑 

分 类 号：R681[医药卫生—骨科学]