Tumor-infiltrating regulatory T cell:A promising therapeutic target in tumor microenvironment  

作　　者：Tianning Huang Fan Li Yiming Wang Jian Gu Ling Lu 

机构地区：[1]Department of Plastic and Cosmetic Surgery of the Affiliated Friendship Plastic Surgery Hospital&Hepatobiliary Center of the First Affiliated Hospital,Nanjing Medical University,Nanjing,Jiangsu 210029,China [2]Research Unit of Liver Transplantation and Transplant Immunology,Chinese Academy of Medical Sciences,Nanjing,Jiangsu 210029,China [3]Department of Liver Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [4]Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221011,China

出　　处：《Chinese Medical Journal》2024年第24期2996-3009,共14页中华医学杂志(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.81971495,82171759,and 82101873);the CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-035);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX23_0706).

摘　　要：Regulatory T cell(Tregs)predominantly maintain the immune balance and prevent autoimmunity via their immunosuppressive functions.However,tumor-infiltrating Tregs(TI-Tregs)may mediate tumor immune tolerance in complex tumor microenvironments,resulting in poor prognosis.Distinguishing specific TI-Treg subpopulations from peripheral Tregs and intratumoral conventional T cells(Tconvs)has recently emerged as an important topic in antitumor therapy.In this review,we summarize novel therapeutic approaches targeting both the metabolic pathways and hallmarks of TI-Tregs in preclinical and clinical studies.Although the phenotypic and functional diversity of TI-Tregs remains unclear,our review provides new insights into TI-Tregbased therapies and facilitates precision medicine for tumor treatment.

关 键 词：Regulatory T cells Tumour microenvironment Tumor infiltrating lymphocyte Immune escape Precision therapy 

分 类 号：R73[医药卫生—肿瘤]