Optical clearing agent combined with hemoporfin-mediated photodynamic therapy for improved efficacy of port-wine stain patients:A pilot study  

作　　者：Jingjing Wen Yamin Zhang Zhen Cai Congcong Wang Jinjin Zhu Lianbin Zhang Jintao Zhu Yan Li Juan Tao 

机构地区：[1]Department of Dermatology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology(HUST),Wuhan,Hubei 430022,China [2]Hubei Engineering Research Center of Skin Disease Theranostics and Health,Wuhan,Hubei 430022,China [3]The First Affiliated Hospital of Xinxiang Medical University,Xinxiang,Henan 453000,China [4]Hubei Engineering Research Center for Biomaterials and Medical Protective Materials,School of Chemistry and Chemical Engineering,HUST,Wuhan,Hubei 430022,China

出　　处：《Chinese Medical Journal》2024年第24期3145-3147,共3页中华医学杂志(英文版)

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.82203924,82130089,and 82003366);Key Research Program of Hubei province(No.2021BCA120);China Postdoctoral Science Foundation(No.2022M721265).

摘　　要：To the Editor:Photodynamic therapy(PDT)is an alternative treatment option for port-wine stains(PWSs)and offers several advantages over pulsed dye lasers(PDLs).^([1])However,some patients still experience treatment resistance and significant side effects.^([1])Optical clearing agent(OCA)has been shown to enhance light penetration in mouse models.^([2])Therefore,we aimed to assess whether combined OCA pretreatment can improve clinical PDT therapy outcomes and investigate the effectiveness of different types of OCA,especially hyaluronic acid microneedles(HA-MNs),in enhancing PDT.

关 键 词：PATIENTS CLEARING agent 

分 类 号：R73[医药卫生—肿瘤]