单纯改良根治术或联合SLNB治疗TNBC的有效性及其预后  

The Effectiveness and Prognosis of Single Line Modified Radical Surgery or Combined SLNB Treatment in TNBC Patients

作　　者：任莎莎 李振宇[1] 冯云[1] REN Shasha;LI Zhenyu;FENG Yun(Luoyang Central Hospital,Luoyang,471000)

机构地区：[1]河南省洛阳市中心医院,471000

出　　处：《实用癌症杂志》2025年第2期247-250,共4页The Practical Journal of Cancer

基　　金：河南省医学科技攻关计划项目(编号:LHGJ20200868)。

摘　　要：目的 分析三阴性乳腺癌(triple negative breast cancer, TNBC)患者应用改良根治术或联合前哨淋巴结活检术(sentinel lymph node biopsy, SLNB)治疗的有效性及预后。方法 收治96例TNBC患者,采用双盲法按1∶1水平将入组对象分为两组,对照组48例手术方式为改良根治术,观察组48例选择SLNB联合改良根治术。观察两组手术效果、血清标志物,随访1年采用乳腺癌人群特异性问卷(QLQ-BR23)评价总体预后情况,记录患者生存、复发与转移情况。结果 观察组手术时间略长于对照组,出血量、引流量与住院时间等均优于对照组,有统计学意义(P<0.05)。观察组术后CA125、CEA水平低于对照组,而TNF-α、PCT高于对照组,有统计学意义(P<0.05)。QLQ-BR23问卷进行客观调查,观察组上肢症状、乳房症状的评分低于对照组,有统计学意义(P<0.05);且观察组对未来看法、性愉悦、性功能与体象等评分均高于对照组,有统计学意义(P<0.05)。结论 对于TNBC患者应用SLNB联合改良根治术在一定程度上可降低手术创伤性,减轻机体术后炎症反应,降低肿瘤标志物表达水平,对术后总体的预后情况具有积极作用。Objective To analyze the efficacy of modified radical mastectomy or sentinel lymph node biopsy(SLNB)in the treatment of triple negative breast cancer(TNBC)and its impact on the prognosis of patients.Methods 96 patients with TNBC were selected and divided them into 2 groups according to 1:1 level by double-blind method.The control group(48 cases)selected the modified radical surgery,and the observation group(48 cases)selected the SLNB combined with the modified radical surgery.The surgical effect and serum markers of the 2 groups were observed.The overall prognosis was evaluated by the breast cancer population specific questionnaire(QLQ-BR23)during 1-year follow-up,and the survival,recurrence and metastasis of patients was recorded.Results After receiving different surgical plans,the 2 groups of subjects objectively evaluated perioperative indicators.The observation group had slightly higher surgical time than the control group,while other indicators such as bleeding volume,drainage volume,and hospitalization time were statistically lower than the control group.The inter group data analysis showed statistical significance(P<0.05).The postoperative CA125 and CEA data of the observation group were lower than those of the control group,while TNF-α、The PCT data analysis was higher than that of the control group,with statistical significance(P<0.05).The QLQ-BR23 questionnaire was used for objective investigation,and the scores of upper limb symptoms and breast symptoms in the observation group were lower than those in the control group,with statistical significance(P<0.05);Moreover,the results of observing the team's future perception rating data,sexual pleasure,sexual function,and physical appearance were all higher than those of the control group,with statistical significance(P<0.05).Conclusion The application of SLNB combined with modified radical surgery can reduce surgical trauma to a certain extent,alleviate postoperative inflammatory response and tumor marker expression in TNBC patients,and have a positive ef

关 键 词：三阴性乳腺癌 前哨淋巴结活检术 肿瘤标志物 改良根治术 预后 

分 类 号：R737.9[医药卫生—肿瘤]