合并HPV感染对子宫内膜癌患者组织中P53、FSTL1、NF-κB、Cdc2表达的影响  

Influence of HPV infection on expressions of P53,FSTL1,NF-kB and Cdc2 in tissues of patients with endometrial cancer

作　　者：吴秋芳[1] 张定富[1] 陈亚君[1] WU Qiu-fang;ZHANG Ding-fu;CHEN Ya-jun(Jingzhou Central Hospital,Jingzhou,Hubei 434020,China)

机构地区：[1]荆州市中心医院肿瘤科,湖北荆州434020

出　　处：《中华医院感染学杂志》2025年第1期91-96,共6页Chinese Journal of Nosocomiology

基　　金：湖北省科学技术厅项目(202015)。

摘　　要：目的分析合并人乳头瘤病毒(HPV)感染对子宫内膜癌患者组织中P53、卵泡抑素样蛋白1(FSTL1)、核因子κB(NF-κB)、细胞分裂周期蛋白2(Cdc2)表达的影响。方法将2020年11月-2023年11月荆州市中心医院收治的98例子宫内膜癌患者为研究组,另选取同期106例子宫肌瘤患者为对照组,比较两组患者组织中HPV感染情况及P53、FSTL1、NF-κB、Cdc2表达水平,分析HPV感染、P53、FSTL1、NF-κB、Cdc2蛋白表达与子宫内膜癌患者临床特征的关系及HPV感染与P53、FSTL1、NF-κB、Cdc2蛋白表达的关系。结果与对照组比较,研究组HPV、P53、NF-κB、Cdc2阳性比例(33.67%vs.2.83%、44.90%vs.0.00%、78.57%vs.30.19%、38.78%vs.0.00%)更高(P<0.05),FSTL1阳性比例(20.41%vs.67.92%)更低(P<0.05)。HPV阳性子宫内膜癌患者国际妇产科联合会(FIGO)分期Ⅲ/Ⅳ期占比更高(P<0.05);FIGO分期Ⅲ/Ⅳ期、有淋巴结转移、肌层浸润程度≥1/2子宫内膜癌患者P53、NF-κB阳性占比更高(P<0.05);FIGO分期Ⅲ/Ⅳ期、有淋巴结转移子宫内膜癌患者FSTL1阳性占比更低(P<0.05);FIGO分期Ⅲ/Ⅳ期子宫内膜癌患者Cdc2阳性占比更高(P<0.05);HPV阳性子宫内膜癌患者P53、NF-κB、Cdc2阳性占比更高(P<0.05),FSTL1阴性占比更高(P<0.05)。结论子宫内膜癌患者HPV感染风险高,可影响P53、FSTL1、NF-κB、Cdc2在组织中的表达,进而促进疾病的发生及发展。OBJECTIVE To observe the influence of human papillomavirus(HPV)infection on expressions of P53,follistatin-like 1(FSTL1),nuclear factorκB(NF-B)and cell division cyclin 2(Cdc2)in tissues of the patients with endometrial cancer.METHODS Totally 98 patients with endometrial cancer who were treated in Jingzhou Central Hospital from Nov.2020 to Nov.2023 were assigned as the study group,meanwhile,106 patients with uterine fibroids were chosen as the control group.The prevalence of HPV infection and expression levels of P53,FSTLl,NF-κB and Cdc2 in tissues were compared between the two groups of patients.The association of HPV infection,P53,FSTL1,NF-κB,and Cdc2 with the clinical characteristics of the endometrial cancer patients and the association of HPV infection with P53,FSTL1,NF-κB and Cdc2 were observed.RESULTS The proportions of patients with positive HPV,P53,NF-κB and Cdc2 of the study group were 33.67%,44.90%,78.57%and 38.78%,respectively,higher than 2.83%,0,30.19%and 0 of the control group(P<0.05);while the proportion of patients with positive FSTL1 of the study group was 20.41%,lower than 67.92%of the control group(P<0.05).The proportion of patients with International Federation of Gynecology and Obstetrics(FIGO)stageⅢor IⅣwas higher among the endometrial cancer patients with positive HPV(P<0.05).The proportions of patients with positive P53 and NF-κB were higher among the endometrial cancer patients with FIGO stage II or IV,lymphatic metastasis and myometrial invasion degree no less than 1/2(P<0.05);the proportion of patients with positive FSTLI was lower among the endometrial cancer patients with FIGO stageⅢorⅣand lymphatic metastasis(P<0.05);the proportion of patients with positive Cdc2 was higher among the endometrial cancer patients with FIGO stageⅢorⅣ(P<0.05).The proportions of patients with positive P53,NF-B and Cdc2 were higher among the endometrial cancer patients with positive HPV infection(P<0.05);the proportion of patients with negative FSTL1 was higher among the endometrial cancer

关 键 词：人乳头瘤病毒 子宫内膜癌 组织 P53 卵泡抑素样蛋白1 核因子ΚB 细胞分裂周期蛋白2 

分 类 号：R737.33[医药卫生—肿瘤]