神经胶质母细胞瘤与其微环境相互作用的研究进展  

Research progress on the interaction between glioblastoma and its microenvironment

作　　者：付海韬 刘幸[1] 刘玉清[1] FU Hai-tao;LIU Xing;LIU Yu-qing(Beijing Institute of Neurosurgery,Beijing 100070,China)

机构地区：[1]北京市神经外科研究所,北京100070

出　　处：《解剖学报》2025年第1期66-73,共8页Acta Anatomica Sinica

基　　金：国家自然科学基金(82003193)。

摘　　要：胶质母细胞瘤(GBM)是成人最常见的中枢神经系统原发恶性脑肿瘤,中位生存期不足15个月。GBM的肿瘤微环境(TME)包括细胞外基质和多种免疫细胞,包括肿瘤相关巨噬细胞、小胶质细胞及骨髓源性抑制细胞等。这些细胞与肿瘤细胞的相互作用在GBM发生发展过程中起着关键作用。GBM微环境的异质性是许多治疗方法疗效不佳的主要原因之一。因此,了解GBM与其肿瘤微环境相互作用,有助于探索新的靶向治疗策略,有望为患者提供更好的治疗方案,从而改善患者预后。Glioblastoma multiforme(GBM)is the most common primary malignant brain tumor of the central nervous system in adults,with a median survival of less than 15 months.The tumor microenvironment(TME)of GBM includes extracellular matrix and a variety of immune cells,including tumor⁃associated macrophages,microglia and myeloid⁃derived suppressor cells.The interaction between these cells and tumor cells plays a key role in the occurrence and development of GBM.The heterogeneity of GBM microenvironment is one of the main reasons for the poor efficacy of many therapies.Therefore,understanding the interaction between GBM and its tumor microenvironment is helpful to explore new targeted therapeutic strategies,which is expected to provide better treatment options for patients,thereby improving patient prognosis.

关 键 词：胶质母细胞瘤 肿瘤微环境 异质性 肿瘤相关巨噬细胞 

分 类 号：R739[医药卫生—肿瘤]