中性粒细胞在真菌性角膜炎中的作用  

Role of neutrophil in fungal keratitis

作　　者：杨珺铭 罗艳婷 何宏[2] 钟兴武[2] Yang Junming;Luo Yanting;He Hong;Zhong Xingwu(Department of Ophthalmology,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,Hainan Province,China;Hainan Eye Hospital,Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Haikou 570311,Hainan Province,China)

机构地区：[1]海南医科大学第一附属医院眼科,海南省海口市570102 [2]中山大学中山眼科中心海南眼科医院(海南省眼科医院)海南省眼科学重点实验室,海南省海口市570311

出　　处：《国际眼科杂志》2025年第2期230-234,共5页International Eye Science

基　　金：海南省卫生健康科技创新联合项目(No.WSJK2024MS128);海南省临床医学研究中心项目(No.LCYX202406);海南省重点研发项目(No.ZDYF2022SHFZ326)。

摘　　要：真菌性角膜炎是一种高发的致盲性疾病,当前的治疗效果仍不理想。该疾病的发生和进展通常受到真菌毒力及宿主免疫反应的显著影响。在疾病进程中,先天性免疫反应首先被激活,其中中性粒细胞在抗真菌过程中发挥关键作用。虽然中性粒细胞在清除病原体方面具有重要功能,但是其过度或异常激活可能引发组织损伤,从而加重病情。因此,探究中性粒细胞在真菌性角膜炎中的作用机制,对于优化治疗策略至关重要。文章旨在综述中性粒细胞的主要杀菌机制,包括吞噬作用、脱颗粒、中性粒细胞胞外诱捕网(NETs)的形成,并探讨中性粒细胞与巨噬细胞的相互作用,以及其在真菌性角膜炎中的效应及潜在机制。对于真菌性角膜炎机制探究,有利于施行的精准干预并增强其治疗效果。Fungal keratitis represents a significant cause of blindness,with current therapeutic approaches yielding limited success.The disease’s onset and progression are primarily driven by fungal virulence factors and the host’s immune response.The innate immune system is the first to respond,with neutrophils playing a pivotal role in the antifungal defense.Although neutrophils are critical for pathogen clearance,their excessive or abnormal activation can lead to tissue damage,exacerbating the disease.Thus,elucidating the mechanisms underlying neutrophil activity in fungal keratitis is crucial for refining treatment strategies.This article aims to systematically review the principal antimicrobial mechanisms employed by neutrophils,including phagocytosis,degranulation,and the formation of neutrophil extracellular traps(NETs).Furthermore,it explores the crosstalk between neutrophils and macrophages,alongside their collective impact and underlying mechanisms in the context of fungal keratitis.Exploration of the mechanisms of fungal keratitis facilitates precise intervention and enhances the efficacy of treatment.

关 键 词：中性粒细胞 真菌性角膜炎 免疫 巨噬细胞 中性粒细胞胞外诱捕网(NETs) 

分 类 号：R73[医药卫生—肿瘤]