Global and regional trends in the incidence and prevalence of uterine fibroids and attributable risk factors at the national level from 2010 to 2019:A worldwide database study  

作　　者：Yuxin Dai Hongda Chen Jing Yu Jie Cai Bin Lu Min Dai Lan Zhu 

机构地区：[1]Department of Obstetrics and Gynecology,State Key Laboratory of Complex,Severe and Rare Diseases,National Clinical Research Center for Obstetric&Gynecologic Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [2]Center for Prevention and Early Intervention,National Infrastructures for Translational Medicine,Institute of Clinical Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730 [3]Eight-year Medical Doctor Program,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [4]National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China

出　　处：《Chinese Medical Journal》2024年第21期2583-2589,共7页中华医学杂志(英文版)

基　　金：supported by grants from the National High level Hospital Clinical Research Funding(No.2022-PUMCH-A-067);National Natural Science Foundation of China(No.82272724);Beijing Municipal Natural Science Foundation(No.Z220013).

摘　　要：Background:Uterine fibroids(UFs),the most common tumors in women worldwide,may reduce quality of life and daily activities and even lead to adverse fertility and general health events in patients,causing significant societal health and financial burdens.The objective of this study was to evaluate the global burden through epidemiological trends and examine the potential risk factors for UFs at the national level.Methods:Data on the incidence,prevalence,disability-adjusted life years(DALYs),age-standardized incidence rates(ASIRs),age-standardized prevalence rates(ASPRs),and age-standardized DALY rates for UFs were collected,and the associations with the Human Development Index(HDI)and fertility were evaluated.The age trends in the average annual percent change(AAPC)of the incidence and prevalence rates of UFs were evaluated by joinpoint regression analysis.The associations between lifestyle,metabolic,and socioeconomic factors and the ASIRs of UFs were examined using multivariable linear regression analysis.Results:The worldwide incidence and prevalence of UFs have been increasing in the past decade,with AAPCs of 0.27%in the incidence rate and 0.078%in the prevalence rate.During 2010–2019,significant increasing trends in UF ASIR were observed in 52 of 88 countries.The age-specific incidence and prevalence of UFs in most age groups showed increasing trends except for 45–54-year-old women which showed no significant trend.Ecological analysis demonstrated no relationship between the incidence of UFs and the HDI but an inverse association with fertility.The incidence of UFs was positively correlated with alcohol intake,hypertension,overweight,and obesity and negatively correlated with smoking.Conclusion:With the increasing incidence and prevalence worldwide,effective targeted prevention and control of relevant risk factors at the national level should be encouraged to reduce the disease burden of UFs.

关 键 词：Uterine fibroids Global Burden of Disease TREND INCIDENCE PREVALENCE Risk factor 

分 类 号：R73[医药卫生—肿瘤]