人工肝弯曲形中空纤维反应器内传质动力学  

Mass Transfer in a Curved Hollow Fiber Bioreactor for Artificial Liver

作　　者：王子恒 许少锋 余一帆 王子辰 张学昌 WANG Ziheng;XU Shaofeng;YU Yifan;WANG Zichen;ZHANG Xuechang(School of Mechatronics and Energy Engineering,NingboTech University,Ningbo 315100,Zhejiang,China;School of Mechanical Engineering,Zhejiang Sci-Tech University,Hangzhou 310018,China;School of Mechanical Engineering,Zhejiang University,Hangzhou 310027,China)

机构地区：[1]浙大宁波理工学院机电与能源工程学院,浙江宁波315100 [2]浙江理工大学机械工程学院,杭州310018 [3]浙江大学机械工程学院,杭州310027

出　　处：《医用生物力学》2024年第6期1204-1211,共8页Journal of Medical Biomechanics

基　　金：浙江省自然科学基金重点项目(LZ21A020001);宁波市青年科技创新领军人才资助项目(2024QL023)。

摘　　要：目的研究弯曲形中空纤维反应器对人工肝传质动力学的影响,为新型反应器结构优化设计和临床操作参数提供依据。方法采用数值模拟方法,建立三维弯曲形中空纤维反应器计算流体动力学(computational fluid dynamics,CFD)模型,通过K-K方程和达西定律综合考虑反应器内的对流传质与扩散传质,并分析弯曲数量和弯曲幅度对传质行为的影响。结果弯曲形反应器内由于离心力作用会产生Dean涡,促进管程内溶质再混合进而增强扩散传质,同时弯曲形反应器跨膜压大进而增强对流传质,即Dean涡和大的跨膜压共同提高了溶质的清除速率。弯曲数量为0、3、6、9、12且弯曲幅度为1 mm时,胆红素的清除速率分别为113.44、117.95、121.89、129.89、140.57 mL/min;弯曲幅度为0、0.5、1.0、1.5、2.0 mm且弯曲数量为3时,胆红素的清除速率分别为113.44、115.45、117.95、120.16、123.14 mL/mi。结论弯曲形中空纤维反应器有助于提高人工肝的毒素清除效率。Objective To study the effect of a curved hollow-fiber bioreactor on the mass transfer in an artificial liver to provide references for the optimal design of new bioreactor structures and operation parameters for clinical treatment.Methods A computational fluid dynamics(CFD)model of a hollow fiber bioreactor was established using numerical simulation.The diffusion and convection mass transfer in the hollow fiber bioreactor were considered by the K-K equation and Darcy’s law.The effects of the bending count and bending amplitude on the mass transfer behavior in a hollow fiber bioreactor were analyzed.Results Dean vortices were generated in the curved hollow fiber bioreactor owing to the centrifugal force.This promoted solute remixing in the tube and thereby,diffusion mass transfer.Meanwhile,the higher transmembrane pressure in the curved hollow fiber bioreactor also promoted convection mass transfer.Consequently,the Dean vortices and high transmembrane pressure increased the solute clearance rate.When the bending counts were 0,3,6,9,and 12 and the bending amplitude was 1 mm,the bilirubin clearance rates were 113.44,117.95,121.89,129.89,and 140.57 mL/min respectively.When the bending amplitudes were 0,0.5,1.0,1.5,and 2.0 mm and the bending count was three,the bilirubin clearance rates were 113.44,115.45,117.95,120.16,and 123.14 mL/min,respectively.Conclusions The curved hollow fiber bioreactor improved the toxin removal efficiency in the artificial liver.

关 键 词：人工肝 中空纤维反应器 Dean涡 跨膜压 传质动力学 

分 类 号：R318.01[医药卫生—生物医学工程]