乳酸调控慢性肝病的研究现状  

Research status of lactate regulation of chronic liver disease

作　　者：汪磊[1,2] 白佳鑫[2] 庄玉玲 王佳慧 赵铁建 黄娜 郑洋[2] 肖华业 WANG Lei;BAI Jia-xin;ZHUANG Yu-ling;WANG Jia-hui;ZHAO Tie-jan;HUANG Na;ZENG Yang;XIAO Hua-ye(Graduate School,Guangxi University of Chinese Medicine,Nanning 530222,Guangxi ZhuangAutonomous Region,China;Faculty of Chinese Medicine Science,Guangxi University of Chinese Medicine,Nanning 530222,Guangxi ZhuangAutonomous Region,China)

机构地区：[1]广西中医药大学研究生学院,广西壮族自治区南宁530222 [2]广西中医药大学赛恩斯新医药学院,广西壮族自治区南宁530222

出　　处：《中国临床药理学杂志》2025年第1期111-115,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(82204755);广西自然科学基金青年基金资助项目(2023GXNSFBA026274,2024GXNSFAA010235);广西研究生教育创新计划基金资助项目(YCBZ2024150);广西壮瑶药重点实验室基金资助项目(GXZYYKF2023-05);广西中医药大学赛恩斯新医药学院科研基金资助项目(2023MS008);广西中医药大学赛恩斯新医药学院国家级大学生创新创业训练基金资助项目(202413643018);广西中医药大学赛恩斯新医药学院科研基金资助项目(2024ZZA002,2024ZZA003,2024ZZB007,2024ZZB010)。

摘　　要：脂肪堆积过多、病毒感染以及非酒精性和酒精性因素引起的持续炎症反应会导致肝炎症、纤维化和癌变,促进慢性肝病的发展。深入了解导致慢性肝病的病因和内在机制,有助于确定潜在的靶向治疗目标。乳酸作为肝代谢中的一种重要物质,可以通过多种途径参与慢性肝病的进程,本综述将为慢性肝病防治提供有益参考。Excessive fat accumulation,viral infections and sustained inflammatory responses caused by non-alcoholic and alcoholic factors can contribute to liver inflammation,fibrosis and carcinogenesis,promoting the development of chronic liver disease.Gaining an in-depth understanding of the etiologic factors and underlying mechanisms that lead to chronic liver disease can help identify potential therapeutic targets for targeted therapy.Lactate,as an important substance in hepatic metabolism,has been found to be involved in the process of chronic liver disease through various pathways,and this review will provide a useful reference for the prevention and treatment of chronic liver disease.

关 键 词：乳酸 慢性肝病 免疫反应 氧化应激 能量代谢 线粒体动力学 

分 类 号：R285.5[医药卫生—中药学]