Hybrid nanostructures for neurodegenerative disease theranostics:the art in the combination of biomembrane and non-biomembrane nanostructures  

作　　者：Chao Gao Ran Xiong Zhi-yu Zhang Hua Peng Yuan-kai Gu Wei Xu Wei-ting Yang Yan Liu Jie Gao You Yin 

机构地区：[1]Department of Neurology,Second Affiliated Hospital(Shanghai Changzheng Hospital)of Naval Medical University,Shanghai 200003,China [2]Department of Neurology,Shanghai East Hospital,School of Medicine,Tongji University,Shanghai 200120,China [3]Department of Health Management,Second Affliated Hospital(Shanghai Changzheng Hospital)of Naval Medical University,Shanghai 200003,China [4]Department of Clinical Pharmacy,Xinhua Hospital,Clinical Pharmacy Innovation Institute,Shanghai Jiao Tong University School of Medicine,Shanghai 200000,China [5]Clinical Pharmacy Innovation Institute,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [6]Changhai Clinical Research Unit,Shanghai Changhai Hospital,Naval Medical University,Shanghai 200433,China [7]Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices,Shanghai 200433,China

出　　处：《Translational Neurodegeneration》2024年第1期462-477,共16页转化神经变性病(英文)

基　　金：supported by the Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission(23Y11906600);the Shanghai Natural Science Foundation(22ZR147750);the Innovative Clinical Research Project of Shanghai Changzheng Hospital(2023YJBF-PY13,2020YLCYJ-Y02,2020CZWJFW12);the Doctoral Innovation Fund of Shanghai Changzheng Hospital(BSCX2023-19,BSCX2022-34).

摘　　要：The diagnosis of neurodegenerative diseases(NDDs)remains challenging,and existing therapeutic approaches demonstrate little efficacy.NDD drug delivery can be achieved through the utilization of nanostructures,hence enabling multimodal NDD theranostics.Nevertheless,both biomembrane and non-biomembrane nanostructures possess intrinsic shortcomings that must be addressed by hybridization to create novel nanostructures with versatile applications in NDD theranostics.Hybrid nanostructures display improved biocompatibility,inherent targeting capabilities,intelligent responsiveness,and controlled drug release.This paper provides a concise overview of the latest developments in hybrid nanostructures for NDD theranostics and emphasizes various engineering methodologies for the integration of diverse nanostructures,including liposomes,exosomes,cell membranes,and non-biomembrane nanostructures such as polymers,metals,and hydrogels.The use of a combination technique can significantly augment the precision,intelligence,and efficacy of hybrid nanostructures,therefore functioning as a more robust theranostic approach for NDDs.This paper also addresses the issues that arise in the therapeutic translation of hybrid nanostructures and explores potential future prospects in this field.

关 键 词：Neurodegenerative diseases BIOMEMBRANE Hybrid nanostructure Alzheimer’s disease Parkinson’s disease Diagnosis 

分 类 号：R741[医药卫生—神经病学与精神病学]