Linking APOE4/4 genotype to microglial lipid droplets and neurotoxicity in Alzheimer’s disease  

作　　者：Hao Huang Rong Xiang Riqiang Yan 

机构地区：[1]Department of Cell Biology,School of Life Sciences,Central South University,Changsha,Hunan,China [2]Hunan Key Laboratory of Organ Fibrosis,Central South University,Changsha,Hunan,China [3]Department of Neuroscience,University of Connecticut Health,Farmington,CT,USA

出　　处：《Translational Neurodegeneration》2024年第1期547-550,共4页转化神经变性病(英文)

基　　金：supported by the National Natural Science Foundation of China(82300787,82170598);the Hunan Provincial Key Field R&D Plan Project(2022SK2034);the Natural Science Foundation of Hunan Province(2022JJ30058);the Youth Science Foundation of Xiangya Hospital(2021Q11).

摘　　要：Alzheimer’s disease(AD)is characterized by progressive cognitive decline and is a neurodegenerative disorder that primarily affects the elderly population worldwide.The main neuropathological features of AD include the development of two pathological hallmarks:intraneu-ronal neurofibrillary tangles and extracellular amyloid plaques,which are often surrounded by microglia,reac-tive astrocytes and dystrophic neurites[1].Despite extensive research,the etiology and detailed molecular mechanisms of AD remain an intriguing enigma.

关 键 词：Alzheimer AMYLOID SPITE 

分 类 号：R74[医药卫生—神经病学与精神病学]