DOPA-decarboxylase is elevated in CSF,but not plasma,in prodromal and de novo Parkinson’s disease  

作　　者：Ellen Appleton Shervin Khosousi Michael Ta Michael Nalls Andrew B.Singleton Andrea Sturchio Ioanna Markaki Wojciech Paslawski Hirotaka Iwaki Per Svenningsson 

机构地区：[1]Laboratory of Translational Neuropharmacology,Department of Clinical Neuroscience,Karolinska Institutet,Stockholm,Sweden [2]Center for Alzheimer’s and Related Dementias,National Institute On Aging and National Institute of Neurological Disorders and Stroke,National Institutes of Health,Bethesda,MD,USA [3]DataTecnica LLC,Washington,DC,USA [4]Laboratory of Neurogenetics,National Institute On Aging,National Institutes of Health,Bethesda,MD,USA [5]James J.and Joan A.Gardner Family Center for Parkinson’s Disease and Movement Disorders,Department of Neurology,University of Cincinnati,Cincinnati,OH,USA [6]Basic and Clinical Neuroscience,King’s College London,London,UK

出　　处：《Translational Neurodegeneration》2024年第1期692-695,共4页转化神经变性病(英文)

基　　金：supported in part by the Intramural Research Program of the National Institute on Aging(NIA),the Center for Alzheimer’s and Related Dementias(CARD),within the Intramural Research Program of the National Institute on Aging and the National Institute of Neurological Disorders and Stroke(AG000546).

摘　　要：Parkinson’s disease(PD)diagnosis is based solely on clinical presentation[1].Therefore,diagnostic and prog-nostic biomarkers are needed.In recent years,seeding aggregation assays(SAA)have demonstrated the ability to discriminate PD from controls,showing also potential as a predictive marker[2].Furthermore,the development of modern proteomic techniques such as the proxim-ity extension assay(PEA)has enabled high throughput,highly sensitive multiplexing studies to become more prevalent.In the past year,several such studies identi-fied DOPA decarboxylase(DDC)as an analyte of par-ticular interest,demonstrating consistent elevation in Lewy body diseases and promising diagnostic potential.

关 键 词：ELEVATED diagnosis clinical 

分 类 号：R742.5[医药卫生—神经病学与精神病学]