Therapeutics for neurodegenerative diseases by targeting the gut microbiome:from bench to bedside  

作　　者：Yuan-Yuan Ma Xin Li Jin-Tai Yu Yan-Jiang Wang 

机构地区：[1]Department of Neurology and Centre for Clinical Neuroscience,Daping Hospital,Third Military Medical University,Chongqing 400042,China [2]Institute of Brain and Intelligence,Third Military Medical University,Chongqing 400042,China [3]Chongqing Key Laboratory of Ageing and Brain Diseases,Chongqing 400042,China [4]Army 953 Hospital,Shigatse Branch of Xinqiao Hospital,Third Military Medical University,Shigatse 857000,China [5]Department of Neurology and National Center for Neurological Disorders,Huashan Hospital,State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science,Shanghai Medical College,Fudan University,Shanghai 200040,China

出　　处：《Translational Neurodegeneration》2024年第1期904-920,共17页转化神经变性病(英文)

基　　金：supported by the National Natural Science Foundation of China(92249305)and the Special Funding for Chongqing Postdoctoral Research Project.

摘　　要：The aetiologies and origins of neurodegenerative diseases,such as Alzheimer’s disease(AD),Parkinson’s disease(PD),amyotrophic lateral sclerosis(ALS)and Huntington’s disease(HD),are complex and multifaceted.A growing body of evidence suggests that the gut microbiome plays crucial roles in the development and progression of neurodegenerative diseases.Clinicians have come to realize that therapeutics targeting the gut microbiome have the potential to halt the progression of neurodegenerative diseases.This narrative review examines the alterations in the gut microbiome in AD,PD,ALS and HD,highlighting the close relationship between the gut microbiome and the brain in neurodegenerative diseases.Processes that mediate the gut microbiome-brain communication in neurodegenerative diseases,including the immunological,vagus nerve and circulatory pathways,are evaluated.Furthermore,we summarize potential therapeutics for neurodegenerative diseases that modify the gut microbiome and its metabolites,including diets,probiotics and prebiotics,microbial metabolites,antibacterials and faecal microbiome transplantation.Finally,current challenges and future directions are discussed.

关 键 词：Neurodegenerative disease Gut microbiome Immune system Vagus nerve Circulatory system Microbiome-targeted therapies 

分 类 号：R74[医药卫生—神经病学与精神病学]