Life and disease status of patients with Parkinson’s disease during and after zero-COVID in China:an online survey  

作　　者：Pei Huang Yu-Yan Tan Biao Chen Hui-Fang Shang Li-Juan Wang Chun-Feng Liu Ling Chen Ying Chang Han Wang Xue-Lian Wang Xiao-Guang Lei Li-Fen Yao Yang Yu Zheng Ye Hai-Bo Chen Sheng-Di Chen 

机构地区：[1]Department of Neurology and Institute of Neurology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Department of Neurology,Xuan Wu Hospital Affiliated to Capital Medical University,Beijing 100053,China [3]Department of Neurology,West China Hospital,Sichuan University,Chengdu 610041,China [4]Department of Neurology,Guangdong General Hospital,Guangzhou 510080,China [5]Department of Neurology,Suzhou Clinical Research Center of Neurological Disease,The Second Affiliated Hospital of Soochow University,Suzhou 215004,China [6]Department of Neurology,The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China [7]Department of Neurology,China-Japan Union Hospital,Jilin University,Changchun 130031,China [8]Department of Neurology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China [9]Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu 610041,China [10]Department of Neurology,The First Affiliated Hospital of Kunming Medical University,Kunming 650032,China [11]Department of Neurology,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China [12]Department of Neurology,Tianjin Huanhu Hospital,Tianjin 300350,China [13]Institute of Neuroscience,Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,Shanghai 200031,China [14]Department of Neurology,Beijing Hospital,National Center of Gerontology,Beijing 100730,China [15]Lab for Translational Research of Neurodegenerative Diseases,Shanghai Institute for Advanced Immunochemical Studies(SIAIS),Shanghai Tech University,Shanghai 201210,China

出　　处：《Translational Neurodegeneration》2024年第1期980-990,共11页转化神经变性病(英文)

基　　金：supported in part by grants from the National Natural Science Foundation of China(82171401,81971187,81971183,82371414);Shanghai Municipal Science and Technology Major Project(2018SHZDZX05).

摘　　要：Background Little is known about the impact of the COVID-19 pandemic on patients with Parkinson’s disease(PD)at different stages of the pandemic.This study aims to assess the lives and disease status of PD patients during the zero-COVID policy period and after ending the zero-COVID policy.Methods This multicenter cross-sectional study included two online surveys among PD patients in China,from May 30 to June 30 in 2022 and from January 1 to February 28 in 2023,respectively.The survey questionnaires contained four sections:(1)status of COVID-19 infection;(2)impact on motor and non-motor symptoms;(3)impact on daily and social lives;and(4)impact on PD disease management.Results A total of 1764 PD patients participated in the first online survey,with 200 patients having lockdown experience and 3 being COVID-19-positive(0.17%).In addition,537 patients participated in the second online survey,with 467 patients having COVID-19 infection(86.96%).(1)During zero-COVID,all of the COVID-19-positive patients had mild symptoms of COVID-19 and no death was reported.After zero-COVID,83.51%of the COVID-19-positive patients had mild symptoms.The overall death rate and inpatient mortality rate of COVID-19-positive PD patients were 3.21%and 30.00%,respectively.(2)During zero-COVID,49.43%of PD patients reported worsening of PD-related symptoms(lockdown vs.unlockdown,60.50%vs.48.02%,P=0.0009).After zero-COVID,54.93%of PD patients reported worsening of PD-related symptoms(COVID-19 positive vs.COVID-19 negative,59.31%vs.25.71%,P<0.0001).(3)During zero-COVID,62.36%of patients felt worried,and‘limited outdoor activities’(55.39%)was the top reason for mental health problems.After zero-COVID,59.03%of patients felt worried,with‘poor health’(58.10%)being the top reason.The PD patients tended to change their daily activities from offline to online,and their economic and caregiver burdens increased both during and after zero-COVID.(4)Most PD patients would like to choose online rehabilitation during(69.56%)and after zero-COVID(69.27%)

关 键 词：COVID-19 Parkinson’s disease Lockdown INFECTION Zero-COVID 

分 类 号：R742.5[医药卫生—神经病学与精神病学]