中药调控JAK2/STAT3信号通路治疗卵巢癌的研究进展  

Chinese Medicine Regulates JAK2/STAT3 Signaling Pathway to Treat Ovarian Cancer:A Review

作　　者：张悦[1] 丁丹妮 李佳 马文文 韩凤娟[2] ZHANG Yue;DING Danni;LI Jia;MA Wenwen;HAN Fengjuan(Heilongjiang University of Chinese Medicine,Harbin 150040,China;First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《中国实验方剂学杂志》2025年第3期323-330,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(82074484、82274566)。

摘　　要：卵巢癌(OC)是女性常见恶性肿瘤之一,死亡率高居妇科恶性肿瘤首位。由于OC早期阶段的非典型症状难以察觉,大多数患者确诊时已是晚期,故临床治疗效果不佳。目前OC的主要治疗方式以手术加化疗为主,但易出现耐药性及不良反应等问题,严重降低了患者生活质量。近年来,中医药因其高效、不良反应小等特点而受到广大临床医生和研究人员的关注。在此基础上,以中医辨证论治为指导,以针对OC发生发展所涉及的分子靶点研究为重点,能够筛选出具有多靶点、范围广、不良反应低的中药,从而更好地发挥中医药治疗OC的独特优势。现代研究表明,OC的发生发展与多条信号通路的异常表达密切相关,酪氨酸蛋白激酶2(JAK2)/转录激活因子3(STAT3)信号通路的持续异常激活可导致OC异常增殖和恶性转化,与OC的发生发展联系密切。诸多研究表明,中药能够通过调控JAK2/STAT3信号通路抑制OC细胞增殖、血管生成、侵袭及转移,促进OC细胞自噬和凋亡,为OC的防治提供新的治疗思路。因此,该文通过梳理国内外相关文献,对JAK2/STAT3信号通路在OC发生发展中的作用进行梳理总结,从中药单体化合物、中药复方等方面围绕中医药通过调控JAK2/STAT3信号通路干预OC发生发展的作用机制及研究进展进行综述,以期为OC的临床研究与药物研制提供系统的科学参考。Ovarian cancer(OC)is one of the most common malignant tumors in women,with the mortality rate being the highest among gynaecological malignant tumors.As the atypical symptoms of OC are difficult to be detected in the early stage,most patients are already in the advanced stage when being diagnosed.As a result,the clinical treatment has limited effects.Currently,the main therapies for OC are surgery and chemotherapy,while their drug resistance and adverse reactions seriously reduce the quality of life of patients.In recent years,traditional Chinese medicine(TCM)has attracted the attention of clinicians and researchers because of its high efficacy,low toxicity,and mild side effects.According to the TCM philosophy of treatment based on syndrome differentiation,the Chinese medicines with multiple targets,wide range,and mild side effects can be screened based on the molecular targets involved in the occurrence and development of OC,which can bring out the unique advantages of TCM in the treatment of OC.Modern studies have shown that the occurrence and development of OC are closely related to the abnormal expression of multiple signaling pathways.The continued abnormal activation of the signal transducer and activator of transcription 3(STAT3)signaling pathway can lead to abnormal proliferation and malignancy of OC.cause abnormal proliferation and malignant transformation of OC,which is closely related to the development of OC.In addition,studies have shown that Chinese medicine can inhibit the proliferation,angiogenesis,invasion,and metastasis and promote the autophagy and apoptosis of OC cells by regulating the Janus kinase 2(JAK2)/STAT3 signaling pathway,providing new therapeutic strategies and ideas for the prevention and treatment of OC.This paper summarizes the role of JAK2/STAT3 signaling pathway in OC development by reviewing the relevant articles and reviews the mechanism and research progress of active components and compound prescriptions of Chinese medicine intervening in OC development by regulating the JAK

关 键 词：卵巢癌 酪氨酸蛋白激酶2(JAK2)/转录激活因子3(STAT3)信号通路 作用机制 中医药 研究进展 

分 类 号：R737.31[医药卫生—肿瘤] R285.5[医药卫生—临床医学] R287