全身免疫炎症指数联合LAR对急性胰腺炎患者病情和预后的评估价值  

Evaluation of the systemic immune-inflammatory index and LAR for assessing the condition and prognosis of patients with acute pancreatitis

作　　者：李振亮 梁敏 周学兵[2] 张静[1] 樊瑞军[1] 丁晓玲[3] LI Zhenliang;LIANG Min;ZHOU Xuebing;ZHANG Jing;FAN Ruijun;DING Xiaoling(Clinical Laboratory and Diagnosis Center,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;Department of Gastrointestinal Surgery,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;Department of Gastroenterology,People's Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China)

机构地区：[1]宁夏回族自治区人民医院临床医学检验诊断中心,宁夏银川750002 [2]宁夏回族自治区人民医院胃肠外科,宁夏银川750002 [3]宁夏回族自治区人民医院消化内科,宁夏银川750002

出　　处：《宁夏医学杂志》2025年第1期39-43,F0003,共6页Ningxia Medical Journal

基　　金：宁夏重点研发计划项目(2022CMG03123)。

摘　　要：目的分析全身免疫炎症指数(SⅡ)联合乳酸脱氢酶/白蛋白比值(LAR)对急性胰腺炎患者病情和预后的评估价值。方法回顾性收集198例急性胰腺炎患者的临床资料,根据患者病情的严重程度分为重症组(n=71)和非重症组(n=127)。比较2组患者的生化指标、C-反应蛋白(CRP)、三酰甘油与葡萄糖指数(TyG)、营养风险指数(NRI)、乳酸脱氢酶(LDH)、LAR和SⅡ。根据患者转归情况,将其分成预后良好组(n=140)与预后不良组(n=58),对比患者各项检测指标。通过logistic回归分析评估患者病情程度的影响因素,并利用ROC曲线分析LAR和SⅡ在评估患者病情及预后情况中的诊断效能。结果重症组患者的TyG、CRP、LDH、LAR和SⅡ均高于非重症组,NRI更低;预后良好组患者的TyG、CRP、LDH、LAR和SⅡ均低于预后不良组,NRI比预后不良组更高,差异均有统计学意义(P<0.05)。logistic分析显示,TyG、CRP、NRI、LDH、LAR和SⅡ均是影响患者病情的重要因素(P<0.05);ROC曲线显示,LAR联合SⅡ对病情评估的准确度为0.939,对预后情况评估的准确度为0.958。结论SⅡ联合LAR在急性胰腺炎患者的病情和预后评估中具有较高的应用价值。Objective To analyze the value of the Systemic Immune-Inflammatory Index(SⅡ)combined the Lactate Dehydrogenase/Albumin Ratio(LAR)in assessing the condition and prognosis of patients with acute pancreatitis.Methods Clinical data of 198 patients with acute pancreatitis were retrospectively collected.Patients were divided into severe group(n=71)and non-severe group(n=127)based on the severity.Basic biochemical indicators,Triglyceride Glucose Index(TyG),C-reactive protein(CRP),Lactate Dehydrogenase(LDH),LAR,NRI and SⅡ were compared between the two groups.Patients were also categorized into a good prognosis group(n=140)and a poor prognosis group(n=58)based on outcomes,and various indicators were compared.Logistic regression analysis was used to evaluate factors influencing the severity of the condition,and the diagnostic performance of LAR and SⅡ in assessing patient condition and prognosis was analyzed using ROC curves.Results Patients in the severe group showed higher levels of TyG,CRP,LDH,LAR,and SⅡ compared to the non-severe group,with a lower NRI;patients with a good prognosis had lower levels of TyG,CRP,LDH,LAR and SⅡ compared to those with a poor prognosis,and a higher NRI,with all differences being statistically significant(P<0.05).The TyG,CRP,NRI,LDH,LAR,and SⅡ were significant factors which affecting patient outcomes(P<0.05).ROC curves showed that the combined use of LAR and SⅡ had an accuracy of 0.939 in assessing condition,and 0.958 in assessing prognosis.Conclusion The combination of SⅡ and LAR has significant value in assessing the condition and prognosis of patients with acute pancreatitis.

关 键 词：全身免疫炎症指数 乳酸脱氢酶 白蛋白 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]